[Analysis of the short and long-term results of traditional duodenum-saving resections of the pancreas head and the original resection-draining method of treatment of chronic pancreatitis].

Aim: Compare the short and long-term results of traditional duodenum-saving resections of the pancreas head and the original resection-draining method of the surgery of chronic pancreatitis.

Materials And Methods: There has been the analysis of the immediate and long-term results of various types of duodenum-saving operations in 48 patients with chronic pancreatitis since 2011 to 2020. The patients were divided into two groups: the control group (=26) where typical duodenum-saving operations were performed, and the study group (=22) - the original resection-draining method of surgery.

Biliary Microbiota and Bile Acid Composition in Cholelithiasis.

Background: A functional interplay between BAs and microbial composition in gut is a well-documented phenomenon. In bile, this phenomenon is far less studied, and with this report, we describe the interactions between the BAs and microbiota in this complex biological matrix. .

Biliary Microbiota, Gallstone Disease and Infection with Opisthorchis felineus.

Background: There is increasing interest in the microbiome of the hepatobiliary system. This study investigated the influence of infection with the fish-borne liver fluke, Opisthorchis felineus on the biliary microbiome of residents of the Tomsk region of western Siberia.

Methodology/principal Findings: Samples of bile were provided by 56 study participants, half of who were infected with O.

[THE INDICATORS OF COAGULATION HEMOSTASIS AFTER CRIO-RESECTION OF LIVER].

The article presents results of comparative evaluation of indicators of coagulation hemostasis in 24 patients with focal parasitic and non-parasitic pathology of liver before and after resection of organ with and without frigotherapy. The analysis of condition of coagulation hemostasis was implemented on the basis of results of blood clotting tests and immune enzyme technique of detection of content of factors V, Xl, XII in blood plasma. It is demonstrated that after crio-resection of liver the tendency to normalization of content of factors V and XI is more expressed than in case of common resection of organ.

[Analysis of the short-term and long-term results in surgical treatment of the chronic cystic pancreatitis].

Introduction: In recent years, the practice of abdominal surgery marked increase in the number of patients with pancreatic cysts. Tactics of treatment of this disease is still disputable.

Material And Methods: The article analyzes the treatment of 128 patients with formed pancreatic cysts.

[Hepatolithiasis].

The authors present an analysis of treatment results in 14 patients with hepatolithiasis. An influence of chronic opisthorchosis invasion on the frequency was determined. Hepatolithiasis was detected in 8 (0.

[Internal biliary fistulas as a complication of cholelithiasis].

The authors made an analysis of observations of 46 patients. They describe algorithm and problems of clinico-instrumental and X-ray diagnostics, strategy of operative treatment and postoperative complications.

[The repeated operations for focal liver lesions].

Repeated operations for focal liver lesions were analyzed. 75 patients with parasitic liver lesions (alveococcosis, echinococcosis), 14 patients with liver tumors, 15 patients with cysts and abscesses were included in the study. For the first time patients underwent palliative operations or diagnostic laparotomy.

[Relaparotomy and laparostomy in treatment of early postoperative complications].

The cause-and-effect analysis of early (within 3 weeks after the initial surgery) relaparotomy was made, using the experience of 5286 laparotomized patients, of whom 82 (1,55%) had relaparotomy. The main reason of intraabdominal complications was the initial generalized peritonitis in emergency patients (85,4%). In comparison with data of 30 years prescription, the portion of postoperative peritonitis and bleeding had increased, though the number of eventrations and postoperative ileus, on the contrary, decreased.

[Ten years experience with using directed laparostomy in treatment of diffuse purulent peritonitis].

During the recent ten years operations were made on 331 patients with diffuse purulent peritonitis, 214 of them had traditional management of the postoperative period, 117 were managed using directed laparostomy by the method developed in the clinic. Toxic phase of peritonitis was noted in 66.76%, with the terminal phase--33.

[Change in biochemical and hemostatic indicators in guinea pigs upon administering Ebola virus preparations].

The biochemical and hemostatic parameters were compared in guinea pigs after inoculation of Ebola virus strains lethal and nonlethal for them and of inactivated antigen of this virus. The time course of the main hemostatic and biochemical parameters in animals challenged with the lethal strain of Ebola virus differed much from that in other groups. This permits us to hypothesize that modification of the virus in the course of adaptation to the host results in the appearance of properties boosting the enzymatic processes and, hence, in depletion and failure of antioxidant and hemostatic defence, which aggravates the pathological process.

[Comparative study of methods for determining antibodies to measles virus].

The authors have developed enzyme immunoassay (EIA) for detecting antimeasles antibodies in the serum and compared it to routine methods. Preparation and purification of measles virus antigen used in EIA and optimal conditions of the reaction are described. Results of the routine methods and those of EIA correlated.

[Development and application of an immunoenzyme test system for diagnosing Ebola fever].

Enzyme immunoassay (EIA) test systems for the detection of antigens of and antibodies to Ebola virus were developed and tried. The test system for the detection of Ebola virus antigens based on direct solid-phase EIA detects viral antigens in culture fluid of infected Vero cells, in the blood sera, and in homogenates of infected tissues. Use of this test system allows detection of at least 10 ng of viral proteins or 5.

[Preparation of rabbit antiserum to Ebola virus].

Humoral immunity of rabbits insusceptible to Ebola virus infection were studied after challenge with infectious Ebola virus and inactivated antigen of this virus. Administration of Ebola virus antigen induced the production of specific antibodies in proportion with the antigen dose injected.

[Isolation of purified Ebola virus].

Purified concentrates of Ebola virus were prepared by two methods, adsorption on polyethylenglycol-600 followed by ultracentrifugation in sucrose density gradient and ultrafiltration. The ultrafiltration method permits preparation of concentrated Ebola virus with better preserved virion structure and infective activity than the traditional method.

[The late results of liver resection in repeat operations].

Long-term results after resections of the liver in reoperated patients are described. The operations were performed on 48 patients. Four of them died (8.

[Ultrasonic diagnosis of complications in repeated surgery of the liver].

Ultrasonic examination is an effective noninvasive method in the diagnosis of complications in reoperations on the liver. With the application of the method the cavity of disintegration and sequestration were diagnosed in 86% of patients with complicated alveococcosis. Affection of the elements of the porta hepatis and inferior vena cava was revealed in 82% of patients, which was very important in determining the operability of the process and was of essential significance in planning the volume of liver resection.

[The classification of cryosurgical resections of the liver in reoperated patients].

The authors present a classification of cryosurgical operations in resection of the liver in reoperated patients. The basis of this classification is different combination of usual and cryosurgical (cryoresection and cryodestruction) methods, which allow to increase the radicality of the operations. Ten kinds of cryointerventions (5 radical and 5 palliative) were established.

[Complications after reoperation hepatectomy].

The main cause of lethal outcomes after resection of the liver in reoperations is hemorrhage and hepatic insufficiency. Among most frequent specific complications are right-side pleurisy, formation of the residual cavity and sequestration. Complications are often observed in combinations and require active therapy.

[Cryosurgery of focal lesions of the liver in patients requiring reoperation].

Cryosurgery ++ (cryoresection and cryodestruction) was carried out in 21 of a group of 43 patients (48.8%) during resection and +re-resection of the liver in repeated operations. One patient died.