The current landscape of treatment options for venous thromboembolism: a focus on novel oral anticoagulants.

Background: Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a major cause of morbidity, mortality, and healthcare expenditure. Anticoagulant therapy is recommended for at least 3 months in patients with acute VTE to prevent recurrence. Conventional anticoagulants are associated with inherent limitations including route of administration, required monitoring and dose adjustments, potential for food-drug and drug-drug interactions, unpredictable pharmacokinetics and pharmacodynamics, and possible severe adverse events.

Treatment in an outpatient setting for a patient with an infected, surgical wound with hypergranulation tissue.

The purpose of this article is to describe a multifaceted approach to wound care in an outpatient setting for a patient with an infected, nonhealing surgical wound with hypergranulation tissue following fasciotomy for acute compartment syndrome. A 44-year-old male underwent an anterior and lateral lower extremity compartment fasciotomy and developed a persistent right anterolateral lower leg wound. Thirty-six days after fasciotomy he came to the authors' clinic after 2 failed skin grafts with an infected wound covered in hypergranulation tissue.

Examination of electrode placements and stimulating parameters in treating chronic pain with conventional transcutaneous electrical nerve stimulation (TENS).

Conventional transcutaneous electrical nerve stimulation was applied to 114 patients diagnosed as having peripheral neuropathy (N = 18), peripheral nerve injury (N = 21), radiculopathy (N = 36) and musculoskeletal disorders (N = 39) to determine optimal electrode placements and stimulation parameters for pain relief. Treatment outcomes were assessed primarily through evaluation of the present pain intensity (PPI) rating scale, Immediate improvements in PPI scores occurred in patients in all these diagnostic categories. One month follow-up data on 25 subjects showed that improvement was of limited duration.