Publications by authors named "Mervin Lawrence"
Background: The dose equivalency of fentanyl vs. morphine is widely considered to be approximately 1:100. However, little is known about the effect of age on this ratio when these agents are used as infusions for analgosedation.
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- The study compares the effects of fentanyl and morphine on the occurrence of inpatient delirium in mechanically ventilated patients.
- Results showed that 46.5% of patients treated with fentanyl developed delirium compared to 39.1% for those receiving morphine, suggesting fentanyl may increase delirium risk.
- There was a direct relationship between the dose of opioids used and antipsychotic medication administration, indicating possible implications for patient care and treatment strategies.
Article Synopsis
- A study was conducted in two adult ICUs to compare the effects of continuous infusion of fentanyl versus morphine on patient outcomes during mechanical ventilation.
- The trial included 681 patients and found that those receiving fentanyl had a higher median number of ventilator-free days at Day 28 compared to those on morphine.
- Results suggested that the choice of opioid can significantly impact clinical outcomes, particularly the duration of time patients spent off the ventilator and their overall ICU stay.