Solid-state tailored silver nanocomposites from chitosan: Synthesis, antimicrobial evaluation and molecular docking.

This study thoroughly explores the synthesis, characterization, and antimicrobial efficacy of three α-aminophosphonate-chitosan (α-AP-Cs) compounds and their nano‑silver functionalized organic hybrids. α-AP-Cs derivatives (CU, CT and CSC) were synthesized via an in-situ, one-pot reaction using chitosan and triphenyl-phosphite, with different carbamide-glutaraldehyde crosslinkers; urea-glutaraldehyde, thiourea-glutaraldehyde and semicarbazide-glutaraldehyde, respectively. Subsequently, their corresponding α-AP-Cs‑silver nanocomposites (CU-AgNPs, CT-AgNPs and CSC-AgNPs) were synthesized via solid-state approach.