Association between Human Leukocyte Antigens (HLA-A, -B, and -DR) and end-stage renal disease in Kuwaiti patients awaiting transplantation.

The number of patients with end stage renal disease (ESRD) is increasing considerably worldwide. Human Leukocyte Antigens (HLAs) are relevant for the expression of many immunological diseases and contribute to the development of different nephropathies. Therefore, we aimed from the present work to investigate the possible association between the frequency of HLA-A, -B, and -DR antigens and ESRD in Kuwaiti patients awaiting renal transplant.

Pretransplant detection of anti-endothelial cell antibodies could predict renal allograft outcome.

Objectives: Endothelial cells that line the vasculature are targets for immune-mediated assault through anti-endothelial cell antibodies. The aim of this work was to detect anti-endothelial cell antibodies and describe the association with kidney allograft rejection and graft survival.

Materials And Methods: The study included 60 patients who had undergone live-donor kidney transplant.

Does pre-transplant in vitro detection of anti-endothelial cell antibodies predict renal allograft outcome?

Endothelial cells lining the vasculature proved to be the target for immune-mediated assault, conceivably through the so-called anti-endothelial cell antibodies (AECA). The aim of this work was to detect the AECAs, and to show its correlation with kidney allograft rejection and graft survival. The study included 60 patients who underwent live-donor kidney transplantation.