Authors Reply to Letter to the Editor - In Response to Comment on Raul E. Ruiz-Lozano et al.'s "Predictive Factors for the Prognosis of Vogt-Koyanagi-Harada Disease".

An aggressive treatment, including immunomodulatory therapy, is very important in preventing the development of the chronic recurrent stage in Vogt-Koyanagı-Harada (VKH) disease. However, the way of treatment is not the only factor determining the prognosis, and there are other factors that affect the outcome.

Predictive Factors for the Prognosis of Vogt-Koyanagi-Harada Disease.

Purpose: To identify the prognostic factors in Vogt-Koyanagi-Harada (VKH) disease.

Methods: This study included 23 patients (46 eyes) with acute-phase VKHdivided into two subgroups: Group 1; acute-resolved (10 patients), group 2; chronic-recurrent (13 patients).

Results: Mean age were 29.

Acute retinal necrosis: clinical features, management and outcomes.

Purpose: To evaluate the clinical features, treatment, and visual outcome of patients with acute retinal necrosis (ARN).

Methods: The data of patients were retrospectively reviewed. Factors associated with visual loss and factors affecting the risk for retinal detachment (RD) development were evaluated.

An objective evaluation of lens transparency after vitrectomy surgery with different intravitreal tamponades.

Purpose: To evaluate and compare the effects of different intraocular tamponade agents on lens density after vitrectomy.

Methods: The participating patients were divided into four groups according to the tamponade agent used: a sulfur hexafluoride (SF) group, a perfluoropropane (CF) group, a silicone oil group, and a no tamponade group. Lens density measurements were performed preoperatively and two weeks, one month, and three months postoperatively using a Pentacam HR device with a Scheimpflug camera.

Brain-Derived Neurotrophic Factor in Patients With Age-Related Macular Degeneration and Its Correlation With Retinal Layer Thicknesses.

Purpose: To determine brain-derived neurotrophic factor (BDNF) levels in serum and aqueous humor (AH) and to assess the relationship between BDNF levels and retinal layer thicknesses in age-related macular degeneration (AMD).

Methods: A total of 48 AMD patients (AMD group) that was composed of twenty-three nonexudative and 25 exudative patients and 26 control subjects (control group) were included in the study. Serum and AH BDNF levels were assessed by ELISA method.

An Early Finding of Keratoconus: Increase in Corneal Densitometry.

Purpose: To investigate the corneal densitometry in subclinical keratoconus with normal elevation and pachymetric parameters.

Methods: Patients with clinical keratoconus in one eye and subclinical keratoconus in the fellow eye were identified. The study group was selected from patients with subclinical keratoconus who showed normal results from topographic and Belin-Ambrósio Enhanced Ectasia Display III (BAD) analysis (Kmean <47.