Publications by authors named "Mert Fiskin"
Article Synopsis
- Researchers discovered a specific motif (YDDΦxΦ) in NF-κB pathway substrates that helps these substrates dock with IKK dimers, showing a link between how well they bind and IKK activity, particularly in IκBα phosphorylation and degradation.
- The study suggests that a certain phosphorylation event on this motif reduces its ability to dock with IKK, which can influence NF-κB signaling, and also indicates that disrupting IKK dimerization disrupts substrate binding.
Mitosis induces cellular rearrangements like spindle formation, Golgi fragmentation, and nuclear envelope breakdown. Similar to certain retroviruses, nuclear delivery during entry of human papillomavirus (HPV) genomes is facilitated by mitosis, during which minor capsid protein L2 tethers viral DNA to mitotic chromosomes. However, the mechanism of viral genome delivery and tethering to condensed chromosomes is barely understood.
View Article and Find Full Text PDF