An Experimental Hut Evaluation of PBO-Based and Pyrethroid-Only Nets against the Malaria Vector Reveals a Loss of Bed Nets Efficacy Associated with Metabolic Resistance.

Growing insecticide resistance in malaria vectors is threatening the effectiveness of insecticide-based interventions, including Long Lasting Insecticidal Nets (LLINs). However, the impact of metabolic resistance on the effectiveness of these tools remains poorly characterized. Using experimental hut trials and genotyping of a glutathione S-transferase resistance marker (L119F-), we established that GST-mediated resistance is reducing the efficacy of LLINs against .