Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics.

Rapidly growing tumor cells must synthesize proteins at a high rate and therefore depend on an efficient folding and quality control system for nascent secretory proteins in the endoplasmic reticulum (ER). The ER resident thiol oxidoreductase ERp57 plays an important role in disulfide bond formation. Lentiviral, doxycycline-inducible ERp57 knockdown was combined with irradiation and treatment with chemotherapeutic agents.

Melting of a confined monolayer of magnetized beads.

We present an experimental model system to study two-dimensional phase transitions. This system is composed of a monolayer of millimetric beads interacting through shor range magnetic dipole-dipole interactions. As the system is athermal, a mechanical agitation is used to produce an erratic motion of the beads.

Innate defense regulator peptide 1018 in wound healing and wound infection.

Innate defense regulators (IDRs) are synthetic immunomodulatory versions of natural host defense peptides (HDP). IDRs mediate protection against bacterial challenge in the absence of direct antimicrobial activity, representing a novel approach to anti-infective and anti-inflammatory therapy. Previously, we reported that IDR-1018 selectively induced chemokine responses and suppressed pro-inflammatory responses.

Symmetry breaking in a few-body system with magnetocapillary interactions.

We have experimentally investigated the interactions between floating magnetic spheres which are submitted to a vertical magnetic field, ensuring a tunable repulsion, while capillary forces induce attraction. We emphasize the complex arrangements of floating bodies. The equilibrium distance between particles exhibits hysteresis when the applied magnetic field is modified.

Antiphase synchronization of electrically shaken conducting beads.

When a spherical conducting bead is placed in an electrode, it experiences an electric force. In a plane capacitor, it can undergo a periodic bouncing between the electrodes. Using a fast video camera, we measured the acceleration of the bead and the period of its motion as a function of the applied voltage.

Hysteretic behavior in three-dimensional soap film rearrangements.

We report experiments on soap film configurations in a triangular prism for which the shape factor can be changed continuously. Two stable configurations can be observed for a range of the shape factor h, being the prism-height/edge-length ratio. A hysteretic behavior is found, due to the occurrence of another local minima in the free energy.

Effect of an electric field on an intermittent granular flow.

Granular gravity driven flows of glass beads have been observed in a silo with a flat bottom. A dc high electric field has been applied perpendicularly to the silo to tune the cohesion. The outlet mass flow has been measured.