Publications by authors named "Merlin Pinto"
Article Synopsis
- The study examines the effects of postnatal steroid treatment on the severity of retinopathy of prematurity (ROP) and its impact on how quickly the retina develops in premature infants born at ≤32 weeks gestation or weighing ≤1500 g.
- Out of 1695 infants analyzed, 67% received steroid therapy, revealing that higher doses and longer treatment durations significantly increased the incidence of severe ROP and delayed full vascularization of the retina.
- The findings suggest that the use of postnatal steroids needs to be carefully considered, as they are linked to worse ROP outcomes and slower retinal development in vulnerable infants.
Background: Preterm neonates often require glucocorticoids to manage refractory hypotension, prevent, and treat bronchopulmonary dysplasia. We have investigated the effect of cumulative dose and duration of glucocorticoids on blood pressure and renal function in VLBW infants.
Methods: In this retrospective cohort study, medical records of infants (GA ≤ 35 weeks) born January 2015 to December 2019 were reviewed to extract demographic and clinical characteristics, dose and duration of steroids, blood pressure (BP), and creatinine at the time of discharge from the neonatal intensive care unit.
Context: In spontaneously breathing preterm infants with respiratory distress syndrome (RDS) receiving nasal continuous positive airway pressure, a method of less invasive surfactant administration (LISA) using a thin catheter has been described as an alternative to endotracheal intubation for surfactant delivery to reduce lung injury.
Objective: A systematic review of randomised controlled trials (RCTs) comparing LISA with the standard method of surfactant delivery for clinical outcomes.
Methods: Medline, CENTRAL and Embase databases were searched (until 29 October 2015).
Aim: Guidelines for newborn resuscitation state that if the heart rate does not increase despite adequate ventilation and chest compressions, adrenaline administration should be considered. However, controversy exists around the safety and effectiveness of adrenaline in newborn resuscitation. The aim of this review was to summarise a selection of the current knowledge about adrenaline during resuscitation and evaluate its relevance to newborn infants.
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