Publications by authors named "Merlin Lee Robb"
Front Immunol
February 2023
Article Synopsis
- Immunogens and vaccination strategies can shape how the immune system recognizes virus weak points, like HIV-1's envelope.
- In HIV vaccine trials, responses to specific parts of the envelope were observed to vary; V2 responses were unique to certain regimens, while V3 responses were widespread.
- Strong V3-specific antibody production was linked to a better overall immune response and did not hinder the recognition of other important viral sites, indicating that targeting multiple regions of vulnerability may be beneficial.
Front Immunol
October 2020
Article Synopsis
- The study investigates how immune responses to HIV vaccines differ among participants in UK and Tanzania trials, highlighting variations in IgG recognition of antigenic regions of the HIV Envelope protein.
- Results indicate that after certain boosts, UK participants primarily targeted specific unmodified regions in the Env, while Tanzanian participants focused on different, prominent areas of the protein.
- Overall, after additional vaccinations, both groups displayed improved recognition of HIV components, although UK participants still had a stronger response to key regions of the gp120 protein.
