[Results of therapy in different groups of risk for superficial bladder cancer].

Approximately 10.0% of tumors occurs in the lower urinary tract and morbidity and lethality are constantly on the rise. Over 90% of such tumors registered in Europe and the USA is transitional cell carcinoma.

[Long-term results of formaldehyde].

General and relatively specific regularities in changes of metabolic reactions (according to the activity of certain enzymes of lysosomes, mitochondria, liver and blood serum sialoglycoproteins content, urine excretion of glycoconjugates) in sexually non mature rat offspring, chemically exposed during embryogenesis, were detected.

[Study and evaluation of the health status of various population groups exposed to environmental factors].

The system of indicators for monitoring the early and prepathologic body reactions due to the strength and duration of environmental effects of various nature was experimentally developed. The study of the health status of specific population groups provided the approbation results for the recommended biochemical indicators.

[Comparative biochemical and electron microscopic research on the membrane-damaging action of a chemical carcinogen on the endoplasmic reticulum in vivo and in vitro].

The results of a comparative biochemical and electron-microscopic study of membrane-injuring effect of N-nitrosodimethylamine--a chemical carcinogen widespread in the environment are reviewed. It has been established that in vivo and in vitro membrane-injuring effect of nitrosodimethylamine is characterized by reduced activity of membrane-bound enzymes of endoplasmic reticulum (UDP-glucuronyltransferase and glucose-6-phosphatase) accompanied by alterations in functional morphology of cells and intracellular structure.

[Role of substance P in regulating the feeding behavior and the avoidance reaction in the rabbit].

Similar changes in feeding and avoidance reaction in spite of the way of substance P administration (30 mgk/kg intravenously or 14,8 nmol intraventricular) were found in rabbits with electrodes implanted in various limbic-midbrain structures. Feeding was found to be more sensitive to substance P administration, as it was shown by the decrease of excitability of the hypothalamic "feeding center" and abolishing of the inhibitory and facilitatory effects on this center from the dorsal hippocampus and the midbrain reticular formation, correspondingly. New cortical-subcortical integration under substance P was presented in new characteristics of EEG activity in neocortical areas, both background and in response to stimulation of various limbic-midbrain structures.

Theoretical substantiation and recommendations of a system of biochemical criteria for the evaluation of the pre-pathological state due to the membrane-damaging effect of environmental factors.

Generalizations derived from experimental studies of enzymic disorganization and stability of membranes of cellular structures (microsomes, mitochondria, lysosomes, cytoplasmic membrane) of various organs and systems (liver, kidney, lung, brain, placenta, gonads, alveolar macrophages and others) due to hepato-, neuro-, gonado-, embryotoxic, mutagenic and carcinogenic effect of chemical pollutants of the environment are presented. Evaluation of the membrane-damaging effect taking into account the stage of labilization of biomembranes (according to severity of manifestation) and compensatory defence reactions at the moleculo-cellular level (alveolar macrophages) is recommended. Classification of biochemical methods (according to priority) is proposed for the evaluation of early functional changes during the examination of the health state of the population in dependence on the effect of environmental factors.

[Effect of ethanol on central mechanisms of alimentary and defensive motivation in the rabbit].

A single intravenous administration of ethanol (0.5 g/kg) to rabbits had different effects on the excitability of feeding and defensive motivational centers of the lateral and ventromedial hypothalamus. Ethanol abolished both inhibitory effects of the dorsal hippocampus and facilitatory action of the midbrain reticular formation on alimentary and defensive motivations.

[Functional state of cells and intracellular structures exposed to regeneration stimulators at early stages of the membranotropic effect of environmental chemicals].

The authors provide the biochemical, morphological and morphometry data on the functions of the cells (alveolar macrophages of the lungs) and intracellular structures (lysosomes, microsomes) of the liver and macrophages from rats exposed to a widely spread carcinogen nitrosodimethylamine and to one of pyrimidine derivatives as a stimulant of regeneration processes. It has been demonstrated that the pyrimidine derivative may prevent the unfavourable metabolic effects occurring at the cellular level (alveolar macrophages of the lungs) and cell organelles (lysosomes and endoplasmic network) in the early stages of the membrane-damaging action of nitrosodimethylamine.

[Correlation between the changes in the functional state of enzyme and hormonal systems of the mature rat].

Content of progesterone and cortisol was studied in blood plasma. Activities of organelle-specific enzymes were estimated in mitochondria (malate dehydrogenase, glutamate dehydrogenase, H + ATPase) and in endoplasmic reticulum (inosine-5-diphosphatase) of liver, kidney tissues and blood serum of rats, which were born after the influence of embryotoxic effectors. Correlation was found in alterations of the patterns studied.