From fishing village to atomic town and present: A grounded theory study.

Thurso/Caithness in the United Kingdom has gone through a lot of changes and transitions in the last decades. The decision to build a nuclear reactor test facility in the 1950's in Dounreay/Caithness UK, as well as the current phase of decommissioning impacted not only the technology development but also the social fabric of the community and individuals within it. This study aimed to explore the lived experiences of people impacted by the nuclear project at Dounreay.

Neutronics design of shutdown and control systems for a Zero Power Experiments of chloride-based molten salt fast reactor.

Nuclear power's role as a reliable, baseload, low-carbon source and its importance in achieving clean energy goals are being increasingly recognized with growing urgency around decarbonization of the global energy systems. However, to deliver a long-term sustainable solution, it is essential to develop innovative nuclear technologies for improving the fuel utilization and reducing the nuclear waste disposal challenge. Zero Power Reactors (ZPR) are an essential initial step for developing new nuclear technologies because they allow for testing and refinement in a safe environment before large-scale deployment.

Fleshy red algae mats act as temporary reservoirs for sessile invertebrate biodiversity.

Many coastal ecosystems, such as coral reefs and seagrass meadows, currently experience overgrowth by fleshy algae due to the interplay of local and global stressors. This is usually accompanied by strong decreases in habitat complexity and biodiversity. Recently, persistent, mat-forming fleshy red algae, previously described for the Black Sea and several Atlantic locations, have also been observed in the Mediterranean.

A disruptive approach to eliminating weapon-grade plutonium - Pu burning in a molten salt fast reactor.

The successful implementation of disarmament treaties of the last centuries has led to significant amounts of weapon-grade Plutonium which are currently stored in high security storage facilities. Disposing this Plutonium should be seen as 'good housekeeping' avoiding unnecessary costs and the hazards of storing this material indefinitely. In addition, the disarmament is only brought to a successful end when the Plutonium isn't available for the production of new weapons anymore.

Demand driven salt clean-up in a molten salt fast reactor - Defining a priority list.

The PUREX technology based on aqueous processes is currently the leading reprocessing technology in nuclear energy systems. It seems to be the most developed and established process for light water reactor fuel and the use of solid fuel. However, demand driven development of the nuclear system opens the way to liquid fuelled reactors, and disruptive technology development through the application of an integrated fuel cycle with a direct link to reactor operation.

An innovative way of thinking nuclear waste management - Neutron physics of a reactor directly operating on SNF.

A solution for the nuclear waste problem is the key challenge for an extensive use of nuclear reactors as a major carbon free, sustainable, and applied highly reliable energy source. Partitioning and Transmutation (P&T) promises a solution for improved waste management. Current strategies rely on systems designed in the 60's for the massive production of plutonium.

Predictors of Patient-Reported Function and Pain Outcomes in Operative Ankle Fractures.

Background: Risk factors associated with short-term functional outcomes in patients with operative ankle fractures have been established. However, no previous studies have reported the association between these risk factors and functional outcomes outside of the first postoperative year. We identified predictors of functional and pain outcomes in patients with operative ankle fractures using the Patient Reported Outcomes Measurement System (PROMIS) physical function (PF) and pain interference (PI) measures.

Comparison of modern locked plating and antiglide plating for fixation of osteoporotic distal fibular fractures.

Background: Fractures in osteoporotic patients can be difficult to treat because of poor bone quality and inability to gain screw purchase. The purpose of this study is to compare modern lateral periarticular distal fibula locked plating to antiglide plating in the setting of an osteoporotic, unstable distal fibula fracture.

Methods: AO/OTA 44-B2 distal fibula fractures were created in sixteen paired fresh frozen cadaveric ankles and fixed with a lateral locking plate and an independent lag screw or an antiglide plate with a lag screw through the plate.

Treatment of Acute Jones Fractures Without Weightbearing Restriction.

Jones fractures are reportedly prone to nonunion and generally treated with a period of non-weightbearing or operative treatment. Extended non-weightbearing can have adverse effects, and operative treatment poses various risks. We report the clinical results of patients treated without weightbearing restriction.

Surgeon preferences regarding antibiotic prophylaxis for ballistic fractures.

Background: Scant evidence exists to support antibiotic use for low velocity ballistic fractures (LVBF). We therefore sought to define current practice patterns. We hypothesized that most surgeons prescribe antibiotics for LVBF, prescribing is not driven by institutional protocols, and that decisions are based on protocols utilized for blunt trauma.

Transmutation of All German Transuranium under Nuclear Phase Out Conditions - Is This Feasible from Neutronic Point of View?

The German government has decided for the nuclear phase out, but a decision on a strategy for the management of the highly radioactive waste is not defined yet. Partitioning and Transmutation (P&T) could be considered as a technological option for the management of highly radioactive waste, therefore a wide study has been conducted. In the study group objectives for P&T and the boundary conditions of the phase out have been discussed.

Impact of postoperative nausea and vomiting prophylaxis with dexamethasone on the risk of recurrence of endometrial cancer.

Objective: To assess whether antiemetic doses of dexamethasone are associated with an increased risk of cancer recurrence in women who underwent surgery for endometrial cancer.

Research Design And Methods: This is a retrospective study at an academic university medical center. Women who underwent surgery for endometrial cancer from 2003 to 2007 were identified from a prospectively collected endometrial cancer database.

Gel scaffolds of BMP-2-binding peptide amphiphile nanofibers for spinal arthrodesis.

Peptide amphiphile (PA) nanofibers formed by self-assembly can be customized for specific applications in regenerative medicine through the use of molecules that display bioactive signals on their surfaces. Here, the use of PA nanofibers with binding affinity for the bone promoting growth factor BMP-2 to create a gel scaffold for osteogenesis is reported. With the objective of reducing the amount of BMP-2 used clinically for successful arthrodesis in the spine, amounts of growth factor incorporated in the scaffolds that are 10 to 100 times lower than that those used clinically in collagen scaffolds are used.

An infrastructure for accurate characterization of single-event transients in digital circuits.

We present the architecture and a detailed pre-fabrication analysis of a digital measurement ASIC facilitating long-term irradiation experiments of basic asynchronous circuits, which also demonstrates the suitability of the general approach for obtaining accurate radiation failure models developed in our FATAL project. Our ASIC design combines radiation targets like Muller C-elements and elastic pipelines as well as standard combinational gates and flip-flops with an elaborate on-chip measurement infrastructure. Major architectural challenges result from the fact that the latter must operate reliably under the same radiation conditions the target circuits are exposed to, without wasting precious die area for a rad-hard design.

On the use of a molten salt fast reactor to apply an idealized transmutation scenario for the nuclear phase out.

In the view of transmutation of transuranium (TRU) elements, molten salt fast reactors (MSFRs) offer certain advantages compared to solid fuelled reactor types like sodium cooled fast reactors (SFRs). In the first part these advantages are discussed in comparison with the SFR technology, and the research challenges are analyzed. In the second part cycle studies for the MSFR are given for different configurations--a core with U-238 fertile, a fertile free core, and a core with Th-232 as fertile material.

Clinical and radiographic comparisons of two different radial head implant designs.

Background: There is little comparative data to guide implant choice for radial head replacements. The purpose of this study was to evaluate the clinical and radiographic results between patients who received a smooth-stemmed bipolar radial head implant and patients who received an in-growth monopolar prosthesis.

Methods: Twenty-seven patients requiring a metallic radial head implant in the management of acute or chronic elbow trauma were evaluated.

Species conserved DNA damage response at the inactive human X chromosome.

Chromatin modifications are long known as an essential part of the orchestrated response resulting in the repair of radiation-induced DNA double-strand breaks (DSBs). Only recently, however, the influence of the chromatin architecture itself on the DNA damage response has been recognised. Thus for heterochromatic DSBs the sensing and early recruitment of repair factors to the lesion occurs within the heterochromatic compartments, but the damage sites are subsequently relocated from the inside to the outside of the heterochromatin.

STAT6 expression in glioblastoma promotes invasive growth.

Background: Glioblastoma (GBM) is a highly aggressive malignant primary brain tumor, characterized by rapid growth, diffuse infiltration of cells into both adjacent and remote brain regions, and a generalized resistance to currently available treatment modalities. Recent reports in the literature suggest that Signal Transducers and Activators of Transcription (STATs) play important roles in the regulation of GBM pathophysiology.

Methods: STAT6 protein expression was analyzed by Western blotting in GBM cell lines and by immunohistochemistry in a tissue microarray (TMA) of glioma patient tissues.

[Special care units for the treatment of acutely ill, cognitively impaired geriatric patients in Germany].

During recent years, specialized wards have been established in geriatric hospital departments as a consequence of the growing need of special care for acutely ill older patients, who are also cognitively impaired. However, there are neither established standards nor any commonly agreed concept of care. A written survey among 12 specialized wards in Germany revealed some characteristics of these wards: extended geriatric assessment, special education of staff including validation and gerontopsychiatric issues, and particular equipment/architecture, such as hidden doors and group rooms, and in some cases loop tracks for walking, therapeutic facilities, and 'living rooms' on the wards.

Extra-articular distal tibia fractures: a mechanical evaluation of 4 different treatment methods.

Objective: This cadaveric biomechanical study compared the mechanical properties of standard plating (SP), locked plating (LP), intramedullary nailing (IMN), and angular stable intramedullary nailing (ASN) for the treatment of axially unstable distal tibia metaphyseal fractures (OTA type 43.A3) with an intact fibula.

Methods: A distal tibia metaphyseal fracture was created in 30 fresh frozen cadaveric specimens by performing an osteotomy 30 mm above the plafond.

Intra-articular distal femur fracture extending from an expanded femoral tunnel in an anterior cruciate ligament (ACL) reconstructed knee: a case report.

Anterior cruciate ligament (ACL) reconstruction is a popular surgery with overall good results. However, postoperative fracture is a serious, albeit, rare complication. Femoral tunnel lysis may cause a stress riser effect leading to distal femur fractures after ACL reconstruction.

Scapulothoracic dissociation with acromioclavicular separation: a case report of a novel fixation method.

We present a case of 39-year-old female with a scapulothoracic dissociation and acromioclavicular (AC) separation and who had fixation of the AC joint with a locking plate, coracoclavicular screw, and transarticular AC screw. The coracoclavicular and AC relationships were maintained during postoperative rehabilitation and after hardware removal. Use of a locking plate can lead to good functional outcome without the complications associated with the use of pin and wire constructs or without violating the subacromial space.

Dislocation of the proximal tibiofibular joint in association with a tibial shaft fracture: two case reports and a literature review.

Dislocation of the proximal tibiofibular joint (PTFJ) in association with a displaced tibial shaft fracture and an intact fibula is an exceedingly rare injury. We present 2 cases of tibia fractures associated with an intact fibula and a PTFJ dislocation. The first case involves a man who sustained a closed spiral fracture of the distal tibial shaft, with an intact fibula, an anterolaterally dislocated PTFJ, and a partial tear of the lateral collateral ligament.