Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi-state Markov models.

Introduction: The theoretical framework of the Alzheimer's disease continuum considers transition between stages in a unidirectional manner. Here we examine the rate of reversion from mild cognitive impairment (MCI) to normal cognition (NC) and explore a set of potential variables associated with this phenomenon.

Methods: A total of 985 Spanish community-dwelling individuals aged 70 years and over at baseline were monitored for 5 years.