Publications by authors named "Merilane da Silva Calixto"
Evaluation of the genotoxic effects of formocresol application in vital pulp therapy of primary teeth: a clinical study and meta-analysis.
Clin Oral Investig
September 2018
Article Synopsis
- This study examined whether the use of formocresol in pulp treatments for children could cause mutations in their lymphocytes over a 7-day period.
- Researchers collected blood samples from children before and after pulp therapy, analyzing 2000 cells to assess mutagenicity.
- While no significant mutagenic effects were found in this specific study, the combined meta-analysis suggested caution in the use of formocresol, highlighting its safe use in pediatric dental treatments.
Despite their ubiquitous incidence, little is known about the chromosomal distribution of long interspersed elements (LINEs) in mammalian genomes. Phyllostomid bats, characterized by lineages with distinct trends of chromosomal evolution coupled with remarkable ecological and taxonomic diversity, represent good models to understand how these repetitive sequences contribute to the evolution of genome architecture and its link to lineage diversification. To test the hypothesis that LINE-1 sequences were important modifiers of bat genome architecture, we characterized the distribution of LINE-1-derived sequences on genomes of 13 phyllostomid species within a phylogenetic framework.
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- The study investigated the organization and evolution of bat genomes by analyzing the ribosomal DNA (rDNA) and telomeric sequences across 12 species within the Phyllostomidae family.
- Results showed varying clusters of 45S rDNA genes, primarily located on autosomes, with one exception, while all species had a single site for 5S rDNA also on autosomes.
- The research revealed differences in evolutionary mechanisms affecting genome architecture, including Robertsonian fusion, without loss of telomeric sequences, enhancing understanding of chromosomal evolution in bats.
To investigate whether formocresol, in Buckley's original formulation, used for pulp therapy of deciduous teeth, can have a genotoxic effect. Genotoxicity was tested in lymphocyte cultures from the peripheral blood of children aged 5-10y, in Recife, Pernambuco, Brazil. This was a case-control study.
View Article and Find Full Text PDFThe genus Artibeus represents a highly diverse group of bats from the Neotropical region, with four large species occurring in Brazil. In this paper, a comparative cytogenetic study was carried out on the species Artibeus obscurus Schinz, 1821, Artibeus fimbriatus Gray, 1838, Artibeus lituratus Olfers, 1818 and Artibeus planirostris Spix, 1823 that live sympatrically in the northeast of Brazil, through C-banding, silver staining and DNA-specific fluorochromes (CMA3 and DAPI). All the species had karyotypes with 2n=30,XX and 2n=31,XY1Y2, and FN=56.
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