[Analysis of symptoms and case history data in the set of 353 patients with lung cancer].

Background: Lung cancer (LC) incidence in men in the Czech Republic has been declining since 1995, in women it grows up continually. To analyse the characteristics of recent set of patients (pts) and contribution of their symptoms for diagnostic, treatment and prognosis we carried on the retrospective study on patients from 1st Pulmonary department from 2004-2007.

Methods And Results: Men:women ratio in the set of 353 pts was 2:1.

[Treatment of lung carcinoma patients at the First Department of Tuberculosis and Respiratory Diseases].

Lung carcinoma (BCA) represents the most frequent malignancy in men and the fourth most frequent one in women. In 2004, 5568 persons died from that disease. Study of the lung carcinoma has been the main research program of the First Department of Tuberculosis and Respiratory Diseases of the First Faculty of Medicine, Charles University and General Teaching Hospital since 1960.

[Incidence, diagnostics and therapy of the lung cancer in the Czech Republic in 2003].

Lung cancer epidemic has not ended. According to the data on the incidence and mortality in the Czech Republic it is obvious that both parameters decline in males; the rise in women probably ends. According to the present epidemiological parameters the number of new cases is still very high.

[Diagnostics and indications of surgical treatment of patients with lung carcinoma at the first clinic of TRN of the first faculty of medicine and the VFN Prague in years 2004 to 2005].

Background: Results of the diagnostics and indications of surgical treatment of patients with lung carcinoma (BCA) at the First clinic in years 2004 to 2005 were evaluated in a retrospective study.

Methods And Results: The cohort of 209 patients with the male to female ratio of 2 to 1 included 63 % of current smokers, 22 % of former smokers and 15 % of non-smokers. BCA was diagnosed in significantly earlier age in smokers in comparison to former smokers or non-smokers.

[Lung cancer operability--history and presence].

Review of contemporary publication on the operability of lung cancer in the Czech Republic and in other countries is presented. Since 1912, when 374 cases of lung cancer were described, the incidence has risen and culminated towards the end of the 20th century. From the available treatment modalities, surgery gives the best results.

[Puncture biopsy of peripheral lymph nodes and subcutaneous masses].

Ninety-one consecutive patients with known diagnosis of lung cancer or clinically suspicious malignant tumour underwent fine needle aspiration biopsy of enlarged peripheral lymph nodes or subcutaneous nodular lesions. There were performed 105 fine needle biopsies. Cytological findings of diagnostic value were found out in 56 (53.

[Cytologic diagnosis of pulmonary cancer in the Czech Republic].

Background: Cytological diagnostic of the lung cancer belongs to routine examinations. The aim of our study was to describe the development of the method in the Czech Republic during the last 20 years, and to evaluate the contribution of clinical cytologist and pathologists in this diagnostical method of the bronchogenic carcinoma.

Methods And Results: 61 stations of bronchology in the Czech Republic were requested (interrogatory method), evaluable responses were obtained from 58 stations (95.

[The Pelger-Huët anomaly].

The authors describe a case-history of Pelger-Huët anomaly in a 53-year-old patient with bronchogenic carcinoma. It was not possible to reveal whether an inborn or acquired anomaly was involved. Recent knowledge of this problem is discussed.

[Transparietal puncture aspiration biopsy of the lung and mediastinum].

Background: The contribution of fine needle transparietal aspiration biopsy for the diagnosis of diseases of thoracic organs is generally accepted. The objective of the present study is to evaluate the contribution of this method to the diagnosis of processes in the lung and mediastinum.

Methods And Results: Transparietal fine needle aspiration biopsy was performed in 115 patients, 75 men and 40 women, mean age 59 +/- 10.

[Pulmonary alveolar microlithiasis].

The authors present two of their own observations where, based on the clinical course of the disease and the X-ray finding, they diagnosed the condition as pulmonary alveolar microlithiasis. They present a review of the literature as regards new views on the pathogenesis, diagnosis and therapy of the condition. They evaluate the contribution of scintigraphy 99 mTc, bronchial lavage and X-ray methods with a high differentiating capacity (HRCT).

Tissue polypeptide antigen in bronchogenic carcinoma.

Serum concentrations of tissue polypeptide antigen (TPA) were examined by an immunoradiometric technique in 114 patients with bronchogenic carcinoma and in 55 patients with noncancerous lung diseases. The sensitivity of TPA examination in bronchogenic carcinoma was 67.5% and was increased in advanced stages of the disease.

[Alpha-subunit of human chorionic gonadotropin in bronchogenic carcinoma].

Using radioimmunoassay method the alpha-subunit of human chorionic gonadotropin (alpha-HCG) serum levels were measured in 112 bronchogenic carcinoma patients and in 48 patients with various non-cancerous lung diseases. The aim of this study was to assess the utility of alpha-HCG as a tumor marker for differential diagnosis of lung cancer. The incidence of elevated alpha-HCG serum level bronchogenic carcinoma group was 4.

[Bronchoalveolar carcinoma, its diagnosis, therapy and prognosis].

The authors give an account of 18 patients with morphologically confirmed bronchioalveolar carcinoma, hospitalized at the First Clinic for TB and Respiratory Diseases in 1969-1988. Women predominated in the group at a ratio of 2:1, mean age: women 46.5 years, men 63.

[Symptoms of diseases of the respiratory system and their importance in diagnosis. Summary and conclusions of research].

The status in the sphere of diagnosis of respiratory diseases and the revealed shortcomings in this area stimulated workers of the First Clinic for TB and Respiratory Diseases to elaborate two investigations, the aim of which was to reveal in the course of the eighties (1983-1988) the most important problems in the diagnostic process and thus contribute to the improvement of the present state. Another task was to record developmental trends as regards the contents of the discipline of pneumology. A relatively large number of patients (2207 subjects) and the period of investigation made it possible to draw some general conclusions.

[Beta-2-microglobulin in bronchogenic carcinoma].

In 77 patients with bronchogenic carcinoma and 46 patients with non-tumorous lung diseases the serum concentration of beta-2-microglobulin was assessed. The revealed differences between groups were not statistically significant. The group with bronchogenic carcinoma was sub-divided by morphological types: epidermoid carcinoma, adenocarcinoma, small-cell and large cell carcinoma.

[Testing bronchogenic carcinoma cells for sensitivity to cytostatics in vitro and in cell cultures].

The authors submit the first experience assembled in Czechoslovakia with testing of the sensitivity of bronchogenic carcinoma cells to cytostatics by the HTCA method (Human Tumor Clonogenic Assay). Based on work by A. W.

Histocompatibility locus antigens (HLA) in the epidermoid type of lung carcinoma.

HLA-A and B antigens were determined in a study of 162 patients (93 epidermoid type, 20 adenocarcinoma, 26 small-cell carcinoma and 23 undifferentiated types) with lung cancer. Differences between antigen frequencies in cancer and control populations were studied by chi 2Y analysis or Fisher's exact test. Survival data were analyzed using Cox's model for censored data.

[Hypercalcemia in bronchogenic carcinoma].

In a population of 621 patients with morphologically proven bronchogenic carcinoma the rate of hypercalcaemia in particular morphologic types of bronchogenic carcinoma was ascertained during the establishment of diagnosis. Regardless of type, there were 10.3% of hypercalcaemic patients in the whole population.

HLA antigens and bronchogenic carcinoma.

Twenty-one HLA-A and B antigens were determined in a study of 162 patients with lung cancer. Differences between antigen frequencies in cancer and control populations were determined by chi 2 analysis with Yates correction or Fisher's exact test. Cancer patients had a decreased frequency of the antigen HLA-B40 (pc = 0.