Publications by authors named "Meri Takada"
Article Synopsis
- Fat embolism syndrome (FES) is a serious but rare complication associated with long bone fractures, characterized by inflammation and potential organ damage.
- The study used rats to investigate how neutral fat and fatty acids affect lung-to-body weight ratios, histological changes, and inflammatory cytokine levels in various organs.
- Findings revealed that neutral fat formed emboli in lung capillaries, increasing inflammatory cytokines like IL-1β, IL-6, and TNF-α, while oleic acid elevated cytokine levels without forming emboli, indicating different mechanisms of inflammation.
Article Synopsis
- * The study investigates the role of Rho-kinases (ROCK1 and ROCK2) in the release of the inflammatory marker IL-1β from human monocytic THP-1 cells when exposed to multi-walled carbon nanotubes (MWCNT) and asbestos.
- * Results showed that blocking ROCKs with a specific inhibitor reduced IL-1β secretion caused by MWCNTs and asbestos but not by lipopolysaccharide (LPS), suggesting ROCKs play a crucial role in the inflammatory response triggered by fibrous particles.
Article Synopsis
- Human organic cation transporter 2 (hOCT2) is located in the kidney and helps transport various compounds, including drugs and toxins, into proximal tubular cells.
- Researchers tested multiple drug classes (like analgesics and anti-depressants) using specially cultured cells to see if they could inhibit the transport of a common OCT2 substrate (14C-TEA).
- Several compounds significantly inhibited this uptake, indicating that different drugs can affect how well the kidneys clear substances transported by hOCT2, suggesting the need for more studies on its impact on drug metabolism.
Hydrogen sulfide (H₂S) is a toxic gaseous substance, and accidental exposure to high concentrations of H₂S has been reported to be lethal to humans. Inhaled and absorbed H₂S is partially dissolved within the circulation and causes toxic effects on lymphocytes. However, the mechanisms involved in H₂S toxicity have not been well documented.
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