Co-existence of insulin resistance and high concentrations of circulating oxidized LDL lipids.

Introduction: Insulin metabolism has been previously linked to oxidized low-density lipoproteins (ox-LDL), but corroborating intervention studies are lacking. We investigated whether changes in ox-LDL levels are accompanied by changes in insulin sensitivity in a 32-month life-style intervention study.

Materials And Methods: A 2-month weight reduction was followed by 6-month diet and exercise counselling and a 2-year follow-up period.

Smoking and low serum testosterone associates with high concentration of oxidized LDL.

Background: The interplay between smoking, oxidized low-density lipoprotein cholesterol (ox-LDL) and gonadal hormones has been scarcely investigated.

Aim: To investigate associations in ox-LDL and gonadal hormones in smokers and non-smokers

Methods: Participants (n=164) were obtained from a population cohort of Finnish men aged 40-70 years. The subjects answered a detailed questionnaire on their health behaviour, medication, diseases, and different symptoms, and the hormonal and lipid profiles were measured.