Publications by authors named "Meredith Wickline"
Breast Cancer Res Treat
March 2003
Article Synopsis
- Farnesyl transferase inhibitors (FTIs) target protein modification and may work independently of Ras, showing potential in inducing apoptosis.
- Tamoxifen, used as an estrogen antagonist, can also trigger apoptosis in human breast tumors through its effects on the Bcl2/mitochondrial pathway.
- The study suggests that combining FTIs with tamoxifen can enhance the cell death effect in estrogen receptor-positive breast cancer cells, while the combination shows limited effectiveness in estrogen receptor-negative cells.
