Publications by authors named "Meredith Shephard"
Unlabelled: Establishing effective mitigation strategies to reduce the spread of influenza virus requires an improved understanding of the mechanisms of transmission. We evaluated the use of a controlled human infection model using an H3N2 seasonal influenza virus to study critical aspects of transmission, including symptom progression and the dynamics of virus shedding. Eight volunteers were challenged with influenza A/Perth/16/2009 (H3N2) virus between July and September 2022 at Emory University Hospital.
View Article and Find Full Text PDFSustained community spread of influenza viruses relies on efficient person-to-person transmission. Current experimental transmission systems do not mimic environmental conditions (e.g.
View Article and Find Full Text PDFArticle Synopsis
- Influenza A viruses in swine are genetically diverse and can potentially become pandemics for humans, largely due to low immunity in the population.
- The study introduces a method to assess and prioritize the risk of influenza viruses and analyzes two specific swine-origin strains, particularly focusing on the α-H1 clade strain (α-swH1N2).
- Findings show that while humans lack immunity to α-swH1N2, the virus replicates well in human airway cultures and can spread efficiently among ferrets, indicating it has significant pandemic potential, though prior immunity reduces its impact.
Secondary infection with has contributed significantly to morbidity and mortality during multiple influenza virus pandemics and remains a common threat today. During a concurrent infection, both pathogens can influence the transmission of each other, but the mechanisms behind this are unclear. In this study, condensation air sampling and cyclone bioaerosol sampling were performed using ferrets first infected with the 2009 H1N1 pandemic influenza virus (H1N1pdm09) and secondarily infected with strain D39 (Spn).
View Article and Find Full Text PDFUnlabelled: Secondary infection with has contributed significantly to morbidity and mortality during multiple influenza virus pandemics and remains a common threat today. During a concurrent infection, both pathogens can influence the transmission of each other, but the mechanisms behind this are unclear. In this study, condensation air sampling and cyclone bioaerosol sampling were performed using ferrets first infected with the 2009 H1N1 pandemic influenza virus (H1N1pdm09) and secondarily infected with strain D39 (Spn).
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