The Efficacy of Lidocaine in Disrupting Cocaine Cue-Induced Memory Reconsolidation.

Rational: Cue-induced craving memories, linked to drug-seeking behaviors, require key molecular processes for memory reconsolidation. Lidocaine, a sodium channel blocker, inhibits NMDA receptor activation and suppresses nitric oxide and ERK production. These processes are required for memory re-consolidation; inhibiting them may reduce cue-related craving memories in cocaine dependent subjects.

Prevalence and cervical organism burden among Louisiana women with Trichomonas vaginalis infections.

Trichomonas vaginalis is the most common curable sexually transmitted infection (STI) worldwide. Although predominately asymptomatic, the disease spectrum of trichomoniasis in women is characterized primarily by signs and symptoms of vaginitis, including purulent discharge and localized vulvar pruritus and erythema. Several FDA-cleared nucleic acid amplification tests (NAATs) are available for the diagnosis of T.

Anxiety and anhedonia in depression: Associations with neuroticism and cognitive control.

Background: Despite the fact that higher levels of anxiety and anhedonia in Major Depressive Disorder (MDD) are linked to poorer treatment outcomes, mechanisms contributing to these clinical presentations remain unclear. Neuroticism, impaired cognitive control, and blunted reward learning may be critical processes involved in MDD and may help to explain symptoms of anxiety and anhedonia.

Methods: Using baseline data from patients with early-onset MDD (N = 296) in the Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) trial, we conducted a path analysis to model relationships between neuroticism, cognitive control, and reward learning to levels of anxiety and anhedonia.

Temptation Minus Self-Efficacy in Alcohol Relapse: A Project MATCH Follow-Up.

Objective: Relapse is a crucial event that occurs for many individuals during recovery from alcohol use disorder. This article examines the impact of temptation to drink and self-efficacy to abstain on two distinct aspects of relapse. Causal chain analyses from Project MATCH, a multisite alcoholism treatment trial, provided initial support for the difference between temptation and self-efficacy as a predictor of alcohol use outcomes.

Trends in systemic psoriasis treatment therapies from 1993 through 2010.

Background: Moderate-to-severe psoriasis generally requires systemic therapy, and is often undertreated.

Objective: To determine and analyze what courses of treatment and in what frequency are being utilized to combat psoriasis in the United States.

Methods: Analysis of data from the National Ambulatory Medical Care Survey (NAMCS) and National Hospital Ambulatory Medical Care Survey (NHAMCS) of the National Center for Health Statistics.

Decreasing frequency of office visits on fridays.

Objectives: To determine if the frequency of physician visits on Fridays varied over the course of 1997 to 2010, and if it varied by geographical region.

Methods: Data from the National Ambulatory Medical Care Survey (NAMCS) of the National Center for Health Statistics were analyzed to examine the frequency of office visits with physicians on Friday from 1997 to 2010, and the same data were also stratified by geographical location.

Results: Fewer office visits occurred on Fridays compared to other weekdays, and the percentage of total visits that occurred on Fridays decreased over time (p = 0.