Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent α5-GABA receptors.

GABA can depolarize immature neurons close to the action potential (AP) threshold in development and adult neurogenesis. Nevertheless, GABAergic synapses effectively inhibit AP firing in newborn granule cells of the adult hippocampus as early as two weeks post-mitosis. The underlying mechanisms are largely unclear.

Synaptic properties of newly generated granule cells support sparse coding in the adult hippocampus.

In the adult hippocampus new neurons are continuously generated throughout life and integrate into the existing network via the formation of thousands of new synapses. Adult-born granule cells are known to improve learning and memory at about 3-6 weeks post mitosis by enhancing the brains ability to discriminate similar memory items. However, the underlying mechanisms are still controversial.

Design and construction of a low-cost nose poke system for rodents.

Operant behavioral tasks for animals have long been used to probe the function of multiple brain regions (i.e., understanding the role of dopamine in electrical brain stimulation reward [1], or determining the rewarding properties of feeding oriented brain pathways [2]).