Publications by authors named "Meredith L Diehl"
Objective: To assess optical coherence tomography in differentiating optic disc edema (ODE) due to papilledema and other optic neuropathies from optic nerve head drusen (ONHD).
Methods: Optical coherence tomographic images from 60 subjects (20 with ODE, 20 with ONHD, and 20 control subjects) were assessed qualitatively and quantitatively. Qualitative criteria for ODE included an elevated optic nerve head with smooth internal contour and subretinal hyporeflective space (SHYPS) with recumbent "lazy V" pattern.
Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells.
Am J Physiol Lung Cell Mol Physiol
April 2003
Article Synopsis
- In chronic obstructive pulmonary diseases, the airway epithelium is repeatedly exposed to neutrophil elastase, which influences the extent of epithelial damage or healing.
- Neutrophil elastase enhances the levels of MUC4, a mucin linked to cell signaling pathways involving ErbB receptors, particularly the epidermal growth factor receptor.
- This increase in MUC4 expression is due to an extension of its mRNA stability, leading to greater MUC4 glycoprotein production, suggesting a role in promoting epithelial repair in response to inflammation.