Pattern of summation with fatigue and inhibition of calcium release in rat muscle.

Introduction: Fatigue disrupts muscle force summation and is associated with a decrease in cytoplasmic Ca(2+) concentration. The purpose of this study was to compare summation during fatigue and recovery with summation during dantrolene-induced inhibition of Ca(2+) release.

Methods: Rat medial gastrocnemius muscles were evaluated before and after fatigue, or during exposure to dantrolene.

Impact of length during repetitive contractions on fatigue in rat skeletal muscle.

The magnitude of fatigue resulting from repeated contractions at a short length has been reported to be less than that which occurs with contractions at a long length. However, there have been what appear to be contradictory reports; the rate of fatigue is greater at a short length. The purpose of this study was to evaluate the impact of length on the magnitude and the rate of fatigue resulting from a series of repetitive stimulations.

The length dependence of muscle active force: considerations for parallel elastic properties.

The purpose of this study was to choose between two popular models of skeletal muscle: one with the parallel elastic component in parallel with both the contractile element and the series elastic component (model A), and the other in which it is in parallel with only the contractile element (model B). Passive and total forces were obtained at a variety of muscle lengths for the medial gastrocnemius muscle in anesthetized rats. Passive force was measured before the contraction (passive A) or was estimated for the fascicle length at which peak total force occurred (passive B).