Hexane fraction of induces mitochondria-mediated apoptosis in -infected mice.

Background: Apoptosis is a common pathology in malaria and most antimalarial drugs induce apoptosis during chemotherapy. is an African mistletoe used for the treatment of malaria but its effect on mitochondria-mediated apoptosis is not known.

Methods: Malarial infection was induced by the intraperitoneal injection of NK 65 strain -infected erythrocytes into mice which were treated with graded doses (100-400 mg/kg) of methanol extract (ME), and fractions of -hexane, dichloromethane, ethylacetate and methanol (HF, DF, EF and MF) for 9 days after the confirmation of parasitemia.

Antimalarial and Erythrocyte Membrane Stability Properties of (Engle Van Tiegh) Growing on Cocoa in -Infected Mice.

Introduction: Resistant malaria is a fatal disease. (African Mistletoe) is traditionally used for malarial treatment but this fact has not been scientifically reported.

Methods: (NK65)-infected male Swiss mice (20±2 g) were treated orally and once daily with 100, 200, and 400 mg/kg BW of methanol extract and its respective hexane, dichloromethane and ethyl acetate fractions for 9 days.