Allelic frequency of 2 and genes in isolates from Awka, Anambra, Nigeria.

Introduction: The genetic diversity of correlates with its pathogenicity, therefore design of evidence-based intervention strategies to eradicate malaria requires genetic diversity surveillance. This study characterised the allelic frequencies and genetic diversity of parasites isolated from Awka, Nigeria.

Materials And Methods: Genomic DNA was extracted from 177 isolates and the polymorphic regions of the and genes were genotyped by nested polymerase chain reaction (PCR).

Antimicrobial and toxicological evaluation of ethanol leaf extract of .

The leaves of are used ethnomedically across Africa for the treatment of different diseases its antimicrobial activity as well as toxicological profile were evaluated. Antimicrobial activity against clinical strains of , , , , and were compared with Gentamycin. Toxicological investigation was determined by administering 100 mg/kg, 200 mg/kg and 400 mg/kg of the ethanol leaf extract to male Wistar rats for 21 days with distilled water as control.

Antiplasmodial activity of the ethanolic root bark extract of Icacina senegalensis in mice infected by Plasmodium berghei.

Background: The root of Icacina senegalensis is used for the treatment of malaria and related conditions in southeastern Nigeria.

Methods: To establish its efficacy, the ethanolic root bark extract was investigated as antiplasmodial agent against Plasmodium berghei in mice. A 4-day suppressive test and the curative effect against established infection models of antiplasmodial studies were used.