Thiophenyl Anilato-Based NIR-Emitting Lanthanide (Ln = Er, Yb) Dinuclear Complexes.

By combining Er and Yb ions with 3,6-dithiophene-anilate (ThAn) and scorpionate hydrotris(pyrazol-1-yl)borate (HBpz) ligands new luminescent dinuclear complexes are obtained. The two materials formulated as [((HB(pz))Yb)(μ-thAn)]·4DCM·1.3HO and [((HB(pz))Er)(μ-thAn)]·4DCM·1.

A highly conducting tetrathiafulvalene-tetracarboxylate based dysprosium(iii) 2D metal-organic framework with single molecule magnet behaviour.

The synthesis and whole characterization by a multitechnique approach of an unprecedented dysprosium(iii) 2D metal organic framework (MOF), involving the redox-active tetrathiafulvalene (TTF)-based linker TTF-tetracarboxylate (TTF-TC), are herein reported. The single-crystal X-ray structure, formulated as [Dy(TTF-TC)(HO)]·21HO (1), reveals a complex 2D topology, with hexanuclear Dy clusters as secondary building units (SBUs) interconnected by five linkers, stacked almost parallel in each layer and eclipsed along the [111] direction, leading to the formation of 1D channels filled by water molecules. The mixed valence of the TTF units is confirmed by both bond distance analysis, Raman microscopy and diffuse reflectance spectroscopy, and further supported by band structure calculations, which also predict activated conductivity for this material.

Reliable replicative lifespan determination of yeast with a single-channel microfluidic chip.

Saccharomyces cerevisiae is a powerful model for aging research due to its short lifespan and genetic malleability. Microfluidic devices offer an attractive approach enabling rapid monitoring of hundreds of cells during their entire replicative lifespan (RLS). Yet, key operational issues such as contaminations, cell loss, and cell-aggregates-dependent flow obstruction can hinder RLS experiments.

Prediction of Cardiac ATTR Depletion by NI006 (ALXN2220) Using Mechanistic PK/PD Modeling.

NI006 (aka ALXN2220) is a therapeutic antibody candidate in phase III clinical development for the depletion of amyloid transthyretin (ATTR) in patients with ATTR cardiomyopathy, an infiltrative cardiomyopathy leading to increased left ventricular wall thickness (LVWT). The mode-of-action consists in removal of disease-causing amyloid accumulations by activating phagocytic immune cells, a mechanism without precedent in cardiology. To select a safe and potentially efficacious dose range and treatment duration for a combined first-in-human and proof-of-concept clinical phase Ib study, we developed a mechanistic pharmacokinetic and pharmacodynamic (PK/PD) model that can predict NI006 exposure, its effects on cardiac amyloid load and on LWVT, which is a predictor of heart failure in this disease.

Every problem is embedded in a greater whole.

Peter Drucker pointed out an important distinction between 'doing things right' and 'doing the right thing', which recognised that all problems are embedded in a context and thus can only be understood within their unique contextual setting. Contemporary research practices in clinical medicine often regards contextual factors as potential confounders that will bias effect estimates and thus must be avoided. However rigorous, research devoid of context ultimately deprives users of understanding of the support factors that make research transferable to policy decisions or managing care of individual patients-it stands in the way of 'doing the right thing' in 'real life' settings.

Enhanced Technique for Accurate Localization and Life-Sign Detection of Human Subjects Using Beam-Steering Radar Architectures.

In this work, we propose a signal processing technique for beam-steering radar architectures allowing concurrent two-dimensional (2-D) localization and vital signs monitoring of human subjects. We demonstrated it by using a single-input single-output (SISO) frequencymodulated continuous wave (FMCW) radar which integrates two frequency-scanning antennas (FSAs). This method is capable of isolating the Doppler signal generated by each single subject from the contributions of all the reflections in the monitored environment.

Tunable SIM properties in a family of 3D anilato-based lanthanide-MOFs.

By reacting a 3,6-ditriazolyl-2,5-dihydroxybenzoquinone (HtrzAn) anilato linker with Ln ions (Ln = Dy, Tb, Ho), two different series of polymorphs, formulated as [Ln(trzAn)(HO)] ·10HO (Dy, 1a; Tb, 2a, Ho, 3a) and [Ln(trzAn)(HO)] ·7HO (Dy, 1b, Tb, 2b, Ho, 3b) have been obtained. In these series the two Dy-coordination networks (1a and 1b) and the Tb-coordination polymer (2b) show a Single Ion Magnet (SIM) behavior. 1-3a MOFs show reversible structural flexibility upon removal of a coordinated water molecule from a distorted hexagonal 2D framework to a distorted 3,6-brickwall rectangular 3D structure in [Ln(trzAn)(HO)] ·2HO (Dy, 1a_des; Tb, 2a_des, Ho, 3a_des) involving shrinkage/expansion of the hexagonal-rectangular networks.

Smartphone App for Prehospital ECG Transmission in ST-Elevation Myocardial Infarction Activation: Protocol for a Mixed Methods Study.

Background: Timely diagnosis and treatment for ST-elevation myocardial infarction (STEMI) requires a coordinated response from multiple providers. Rapid intervention is key to reducing mortality and morbidity. Activation of the cardiac catheterization laboratory may occur through verbal communication and may also involve the secure sharing of electrocardiographic images between frontline health care providers and interventional cardiologists.

Which adults aged 65 and older are at low-risk for cervical spine injuries after low-level falls?

Objectives: The population is aging and falls are a common reason for emergency department visits. Appropriate imaging in this population is important. The objectives of this study were to estimate the prevalence of cervical spine injury and identify factors associated with cervical spine injuries in adults ≥ 65 years after low-level falls.

Slow magnetic relaxation in a heteroleptic anilate-based Dy metal-organic framework.

Novel heteroleptic anilate-based lanthanide MOFs (Ln = Tb, Dy, Ho) have been obtained under hydrothermal conditions by the ancillary ligand synthetic strategy. These structurally isomorphous species contain octacoordinated Ln ions with coordination polyhedra approaching an ideal symmetry, best described by a distorted biaugmented trigonal prismatic geometry. In the whole series, only the Dy-MOF exhibits SMM behaviour.

Normative challenges in data governance: insights from global health research.

Many important questions in health professions education require datasets that are built from several sources, in some cases using data collected for a different purpose. In building and maintaining these datasets, project leaders will need to make decisions about the data. While such decisions are often construed as technical, there are several normative concerns, such as who should have access, how the data will be used, how products resulting from the data will be shared, and how to ensure privacy of the individuals the data is about is respected, etc.

Application of the Win Ratio Method in the ENGAGE AF-TIMI 48 Trial Comparing Edoxaban With Warfarin in Patients With Atrial Fibrillation.

Background: Cardiovascular trials often use a composite end point and a time-to-first event model. We sought to compare edoxaban versus warfarin using the win ratio, which offers data complementary to time-to-first event analysis, emphasizing the most severe clinical events.

Methods: ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48) was a double-blind, randomized trial in which patients with atrial fibrillation were assigned 1:1:1 to a higher dose edoxaban regimen (60/30 mg daily), a lower dose edoxaban regimen (30/15 mg daily), or warfarin.

Evaluation of a single-dose HPV vaccine strategy for promoting vaccine, health, and gender equity.

Although several countries have adopted a single-dose human papillomavirus (HPV) vaccination strategy, many other countries continue to include multiple doses in their vaccination programmes. There are ethical reasons to transition to a single-dose strategy. We discuss how a single-dose HPV vaccination strategy advances equity in three dimensions: vaccine equity, health equity, and gender equity.

Tuning the slow magnetic relaxation with the substituents in anilate bridged bis(dysprosium) complexes.

Dinuclear lanthanide complexes [((HB(pz))Dy)(μ-ThAn)] (1Dy) and [((HB(pz))Dy)(μ-ClCNAn)] (2Dy), based on the hydrotris(pyrazol-1-yl)borate (HBpz) scorpionate capping ligand and anilate (An) bridging linkers, namely homosubstituted dithiophene- and heterosubstituted chlorocyanoanilate, bearing electron-donating and withdrawing substituents at the 3,6-positions of the benzoquinone core, are reported. 1Dy shows an octacoordinated {NO} Dy ion within a distorted square antiprismatic coordination, an ideal geometry for Single-Molecule Magnet (SMM) behavior, given its oblate nature, whereas in 2Dy the octacoordinated Dy ion adopts a triangular dodecahedron geometry, while maintaining the same {NO} coordination sphere. Both complexes show field-induced single molecule magnet (SMM) behaviour, with tuning of the slow magnetic relaxation as a function of the nature of the substituents at the 3,6-positions of the anilate moiety.

Emergency physician gender and head computed tomography orders for older adults who have fallen.

Objective: Physicians vary in their computed tomography (CT) scan usage. It remains unclear how physician gender relates to clinical practice or patient outcomes. The aim of this study was to assess the association between physician gender and decision to order head CT scans for older emergency patients who had fallen.

Does hunted wild boar meat meet modern consumer nutritional expectations?

The present study aimed to evaluate the nutritional characteristics of hunted wild boar (WB) meat and compare them with those of meat from analogous domestic animals (pigs) reared in two different rearing systems: indoor-intensive (PI) and outdoor-extensive (PO). WB meat showed a lower amount of lipid content compared to pork and a higher antioxidant activity compared to PI and PO. The comparison of the fatty acid composition of WB and domestic pig reveals significant differences in saturated fatty acids (SFA) and polyunsaturated fatty acids (PUFA), with WB having the highest PUFA level and the lowest SFA level.

Insights into Nd to Yb Energy Transfer and Its Implications in Luminescence Thermometry.

This work challenges the conventional approach of using NdF lifetime changes for evaluating the experimental Nd → Yb energy transfer rate and efficiency. Using near-infrared (NIR) emitting Nd:Yb mixed-metal coordination polymers (CPs), synthesized via solvent-free thermal grinding, we demonstrate that the Nd [H → I] → Yb [F → F] pathway, previously overlooked, dominates energy transfer due to superior energy resonance and -level selection rule compatibility. This finding upends the conventional focus on the Nd [F → I] → Yb [F → F] transition pathway.

A Longitudinal Survey on Canadian Emergency Physician Burnout.

Study Objective: Since Canada eased pandemic restrictions, emergency departments have experienced record levels of patient attendance, wait times, bed blocking, and crowding. The aim of this study was to report Canadian emergency physician burnout rates compared with the same physicians in 2020 and to describe how emergency medicine work has affected emergency physician well-being.

Methods: This longitudinal study on Canadian emergency physician wellness enrolled participants in April 2020.

Derivation of the Falls Decision Rule to exclude intracranial bleeding without head CT in older adults who have fallen.

Background: Ground-level falls are common among older adults and are the most frequent cause of traumatic intracranial bleeding. The aim of this study was to derive a clinical decision rule that safely excludes clinically important intracranial bleeding in older adults who present to the emergency department after a fall, without the need for a computed tomography (CT) scan of the head.

Methods: This prospective cohort study in 11 emergency departments in Canada and the United States enrolled patients aged 65 years or older who presented after falling from standing on level ground, off a chair or toilet seat, or out of bed.

Expediting approval for medical countermeasures to address high burden disease: an ethical justification to move beyond emergency use authorisation.

Addressing global health crises requires a receptive and expedient policy environment to minimise delays in making available potentially life-saving technologies. Over time, the policy environment has adapted to ensure that communities have expedited access to promising technologies, such as vaccines, that can mitigate morbidity and mortality. Emergency authorisations are one such policy mechanism.

A SISO FMCW radar based on inherently frequency scanning antennas for 2-D indoor tracking of multiple subjects.

The contextual non-invasive monitoring and tracking of multiple human targets for health and surveillance purposes is an increasingly investigated application. Radars are good candidates, since they are able to remotely monitor people without raising privacy concerns. However, radar systems are typically based on complex architectures involving multiple channels and antennas, such as multiple-input and multiple-output (MIMO) or electronic beam scanning, resulting also in a high power consumption.

Terbium and Europium Chlorocyananilate-Based 2D Coordination Polymers.

Two-dimensional layered coordination polymers based on the hetero-substituted 3-chloro-6-cyano-2,5-dihydroxybenzoquinone ligands, hereafter ClCNAn anilate, and Ln ions (Tb and Eu) are reported. Compounds and , formulated as Ln(ClCNAn)(DMSO) (Ln = Tb, ; Eu, ), and their related intermediates and , formulated as Ln(ClCNAn)(HO)·yHO (x + y likely = 12, Ln = Tb, ; and Eu, ), were prepared by a conventional one-pot reaction (the latter) and recrystallized from DMSO solvent (the former). Polyhydrated intermediates and show very similar XRPD patterns, while, despite their common stoichiometry, and are not isostructural.