Sustained initial remission induced by intensive insulin treatment in type I diabetes. Possible role of the genetic background.

A remission defined by the possibility of temporarily discontinuing insulin therapy while blood glucose remains normal is not infrequently observed after intensive insulin therapy in newly diagnosed acute type I diabetes in the South of France. In order to analyze possible factors of such a remission, 47 newly diagnosed ketotic diabetics under 35 years of age and of Caucasian origin were enrolled in a prospective study. They were given continuous s.

Ridge form in preprosthetic surgery.

In preprosthetic surgery there is a need for improved methods of diagnosis that are based on the recognition of the anatomy of the deficient residual ridge. These methods enable the surgeon to direct his attention to obtaining the ideal ridge form for denture construction. To this end, characteristics and patterns of resorption as well as a cephalometric method of assessment are presented.

HLA-A, B, DR antigens and insulin-dependent diabetes in Algerians.

HLA-A, B and DR antigens have been investigated in insulin-dependent diabetics and compared to controls in a population of Algerians. A decrease of A1 and DR2 and an increase of Aw 19.2; B8, B18 and especially DR3 were found in diabetics in comparison to controls.

[Early surgery of ruptured aneurysms. A factor in preventing ischemia].

110 patients with ruptured aneurysms were operated on within 4 to 96 hours after subarachnoid hemorrhage. Clinical grades (Hunt) were: 1-2-3 in 93 cases and 4-5 in 17 cases. Among the patients grades 1-2-3, 81% had a good out come without any neurological abnormality, among the patients graded 4-5, only 27% had a fair out come.

[Comparative study of 3 implanted micrografts placed in the abdominal aorta of the rat].

A comparative study was conducted on three micrografts of 2 mm diameter: a frozen umbilical artery, a bovine heterograft and an inert P.T.F.

[Treatment of retinal detachment caused by posterior pole dehiscence].

20 eyes have been treated for a retinal detachment due to a posterior pole break. Three successive, different operative techniques were used: macular silastic sponge, vitrectomy plus internal tamponade by silicone oil, vitrectomy plus internal tamponade by air or by a mixture of air 60% and SF6 40%. Macular sponges obtained a good rate of retinal reattachment (83.

A simplified acute physiology score for ICU patients.

We used 14 easily measured biologic and clinical variables to develop a simple scoring system reflecting the risk of death in ICU patients. The simplified acute physiology score (SAPS) was evaluated in 679 consecutive patients admitted to eight multidisciplinary referral ICUs in France. Surgery accounted for 40% of admissions.

Influence of HLA-A, B, and DR matching on the outcome of kidney transplant survival in preimmunized patients.

The outcome of 893 prospectively typed (HLA-A, B, and DR) and matched cadaveric kidney transplants--all first grafts, with patients being transfused before transplantation--was studied using actuarial survival methods. The effect of HLA-A, B and DR matching was only found to be significantly beneficial to graft survival in the group of 289 presensitized recipients: 70% and 43% graft survival at two years in the case of best-matched (4-6 HLA-A, B, and DR) identities versus mismatched (0 and 1 HLA-A, B, and DR) identities, respectively (P = 0.05).

Transformation of LMTK- cells with purified HLA class I gene. VI. Serological characterization of HLA-B7 and AW24 molecules.

Serological characterization of HLA-B7 and HLA-AW24 class I molecules following transfection of murine LMTK- cells with purified HLA class I genes was performed using human alloantisera. Induction by murine alpha interferon of the expression of class I molecules was required to obtain unambiguous identification of these molecules which appear serologically identical to the HLA-B7 and HLA-AW24 molecules expressed at the surface of human peripheral blood lymphocytes of 20 unrelated individuals. Analysis of the transformed cells with 8 different anti-HLA class I monoclonal antibodies results in the definition of 3 separate clusters of antigenic determinants shared by all HLA class I molecules.

[The anterior tibial artery and vascularization of the muscles of the anterior compartment of the leg. Application to the anterior compartment syndrome of the leg].

The arterial vascularisation of the anterior loge of the leg is supply by the anterior tibial artery. Three muscles are contained in an inextensible space. Each of this muscles received an arterial supply proportional to his volume.

[Anti-B-lymphocyte antibodies in rheumatoid polyarthritis. I.--1st findings in 22 patients].

Anti B and T lymphocyte antibodies were sought in the serum of 22 rheumatoid arthritis patients from the Marseille area. No immunization against T lymphocytes was found. In contrast anti B lymphocyte activity was demonstrated in every diluted serum tested against a panel of 21 cells.

[Spinal cord compression in multiple myeloma. Study of 10 cases].

Ten cases of multiple myeloma with spinal cord compression are reported. The compression was located in the thoracic spine in 9 cases and in the cervical spine in 1 case. It led to the discovery of the myeloma in 4 cases.

Diet-induced thermogenesis with relation to training state in female subjects.

The purpose of this study was to investigate the effect of exercise training on meal-induced thermogenesis in 30 female subjects with an average age of 26 years, an average weight of 53.5 kg, and an average height of 162.4 cm.

HLA and trisomy 21. Confirmation of a trend of restricted HLA heterogeneity in parents of Down syndrome children.

As the HLA system could play a role in the in utero selection process against abnormal fetuses, HLA-A and -B antigens were evidenced in 30 children with trisomy 21 and in their parents, using a standard microlymphocytotoxicity test. The comparison group included 60 families among whom 39 had HLA typing for paternity exclusion and 21 had been previously selected for a segregation study. Both groups consisted of nonconsanguineous Caucasians from the same geographical area.

Mastication after surgical reconstruction of the mandibular residual ridge.

A group of thirty-one female denture patients who underwent surgical reconstruction of their deficient residual ridges with ridge extension and skin graft or ridge augmentation with bone graft were evaluated with regard to their masticatory function before surgery, then at 8 months and 12 months post-operative with their new dentures. Two objectives tests of masticatory efficiency were used. The masticatory efficiency index (MEI), based on the size of chewed almond particles, determined the potential capacity of patients to masticate while the masticatory performance (MP) based on the time required to masticate food before swallowing assessed the individual ability of each patient to chew food.

A radio-anatomical study in vivo on pancreatic ducts.

Pancreatography using fibroscopy is current practice in medicine and contributes to the diagnosis of diseases of the pancreas. The radiographic images obtained generally represent oblique projections which have little in common with classic anatomical diagrams. An analysis of 60 pancreatographic investigations considered normal (out of a series of 400 investigations made on various diseases of the pancreas) has been followed by a comparison between these radiographic results obtained in vivo with diverse anatomical classifications in current use.