Publications by authors named "Mercedes Rubio-Hernandez"
Chagas disease is caused by the eukaryote parasite . Current treatment exhibits limited efficacy and selenium-based compounds emerged as promising candidates for new therapies which is surpassing its bioisoster, sulfur. We designed new thiosemicarbazones, thiazoles, selenosemicarbazones and selenazoles, using isosteric substitution.
View Article and Find Full Text PDFLeishmaniasis remains one of the main public health problems worldwide, with special incidence in the poorest populations. Selenium and its derivatives can be potent therapeutic options against protozoan parasites. In this work, 17 aryl selenoates were synthesized and screened against three species of (, , and ).
View Article and Find Full Text PDFArticle Synopsis
- * Research indicates that sulfur-containing compounds may effectively combat the Trypanosoma cruzi parasite, and substituting sulfur with selenium may enhance their effectiveness.
- * The study evaluates various selenium compounds against their sulfur equivalents to propose new drug candidates for treating Chagas disease, while highlighting the need for further research to confirm their efficacy.
Article Synopsis
- - The parasite Trypanosoma cruzi causes Chagas disease, a major health issue in Latin America, but existing treatments are toxic and not very effective.
- - Researchers have developed 69 new Mannich base derivatives to improve anti-parasitic effectiveness and reduce toxicity by optimizing their chemical properties.
- - Among these, derivative 3c showed strong potential as a new treatment, working well with the current drug benznidazole, making it a promising candidate for further testing in Chagas disease treatment research.