Publications by authors named "Mercedes Maino"
Purpose: Several studies have shown that estrogen receptor (ER) and progesterone receptor (PR) expression and human epidermal growth factor receptor 2 (HER2) expression may vary during tumoral progression. We aimed to describe and compare ER, PR, and HER2 expressions in primary breast tumors and synchronic axillary nodal metastases, and evaluate phenotypic correlations between them.
Methods: Patients were identified prospectively through surgical procedures between September 2013 and July 2016.
Article Synopsis
- - Clinical studies indicate that triple negative breast cancer (TNBC) patients with EGFR-expressing tumors may respond positively to Cetuximab, a drug that targets EGFR, but there’s a noted deficiency in how well NK cells can mediate the cancer-killing effects of this treatment.
- - Researchers identified that high levels of the inhibitory receptor CD85j on NK cells were linked to a reduced ability to attack TNBC cells in the presence of Cetuximab, even when stimulating cytokines were present.
- - Blocking CD85j function with a specific antibody improved NK cell activity against TNBC cells, suggesting that targeting immune activation issues could enhance the effectiveness of Cetuximab therapy in patients.