Publications by authors named "Mercedes Carnethon"

The 2nd recommends ≥2 days of resistance training (RT). Evidence supports a dose-response relation between RT volume and cardiometabolic health. We examined whether RT guidelines and volume were associated with lower all-cause mortality.

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Article Synopsis
  • The study analyzed how different levels of psychosocial stress impact the risk of cardiovascular disease (CVD) over time, using data from the Multi-Ethnic Study of Atherosclerosis (MESA) involving over 6,300 adults.
  • Researchers found five distinct subgroups of psychosocial stress based on self-reported data, with 'high discrimination' being linked to a significantly increased risk of CVD events, even after adjusting for other health factors.
  • Social support, neighborhood cohesion, and physical activity did not significantly alter the relationship between psychosocial stress and CVD risk, indicating that high levels of discrimination and chronic stress are critical factors for cardiovascular health outcomes.
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Sleep and circadian disturbances are common and are experienced more often by Black compared to White individuals. We conducted an observational study of sleep that was ancillary to an ongoing cohort study, Coronary Artery Disease in Young Adults (CARDIA). The goal of the ancillary study will be to examine potential determinants of sleep/circadian disparities between Black and White adults in future analyses.

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  • The study aimed to explore how sleep patterns in early midlife affect brain aging in late midlife using data from the CARDIA study.
  • Researchers analyzed sleep data, focusing on factors like sleep duration and quality, and later assessed brain age through MRIs taken 15 years later.
  • Results showed that individuals with more poor sleep characteristics had significantly older brain ages, emphasizing the need for sleep interventions to support brain health.*
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Background: High rates of physical inactivity persist in the United States, with higher rates among non-Hispanic Black adults than among their White peers. However, a comparison of physical activity engagement across nativity among Black adults in the United States has yet to be fully documented. The purpose of this cross-sectional study was to examine physical activity engagement rates among African immigrant and Afro-Caribbean immigrant adults compared with native-born African American adults using data from the 2010 to 2018 National Health Interview Survey.

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Background: Proximity to urban blue and green spaces has been associated with improved cardiovascular health; however, few studies have examined the role of race and socioeconomic status in these associations.

Methods: Data were from the CARDIA study (Coronary Artery Risk Development in Young Adults). We included longitudinal measurements (1985-1986 to 2010-2011) of blue and green spaces, including percentage of blue space cover, distance to the nearest river, green space cover, and distance to the nearest major park.

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Obesity is a recognized public health epidemic with a prevalence that continues to increase dramatically in nearly all populations, impeding progress in reducing incidence rates of cardiovascular disease. Over the past decade, obesity science has evolved to improve knowledge of its multifactorial causes, identifying important biological causes and sociological determinants of obesity. Treatments for obesity have also continued to develop, with more evidence-based programs for lifestyle modification, new pharmacotherapies, and robust data to support bariatric surgery.

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  • - The study investigates over 2,000 young adults to identify metabolic factors that contribute to weight gain during early adulthood, rather than relying solely on BMI "snapshots."
  • - A unique metabolic signature was found, correlating with an average BMI increase of 2.6% over approximately 20 years for each standard deviation increase in the score, highlighting significant metabolic influences on weight gain.
  • - The research emphasizes the intricate nature of metabolic regulation in weight gain and advises caution when using traditional epidemiological or genetic measures in metabolic studies.
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Background: Youth use different forms of screen time (e.g., streaming, gaming) that may be related to body mass index (BMI).

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Aim: To assess the association of adipose-to-lean ratio (ALR) with incident type 2 diabetes mellitus (T2DM), hypertension, and dyslipidemia in middle adulthood.

Method: Black and White Coronary Artery Risk Development in Young Adults participants without T2DM, hypertension, or dyslipidemia in 2005-06 (baseline) were included. Baseline adipose and lean mass were assessed via dual-energy X-ray absorptiometry.

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Introduction: Limited longitudinal research is available examining how American adults make dietary changes after learning they have diabetes. We examined the associations between diabetes awareness and changes in dietary quality and food intake in a prospective cohort from the Coronary Artery Risk Development in Young Adults (CARDIA) study.

Research Design And Methods: A nested case-control design was used.

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  • - This study examines how social and psychosocial factors influence cardiovascular health (CVH) among different racial/ethnic groups, including Black, Chinese, Hispanic, South Asian, and White participants in the US.
  • - Using data from nearly 8,000 adults, researchers used a specific statistical method to analyze how income, place of birth, and education contribute to differences in CVH scores across these groups.
  • - Findings reveal that improved income and educational equality could potentially raise CVH scores for Black, Hispanic, and South Asian participants, highlighting the impact of social factors on health outcomes in diverse populations.
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Background And Objective: Growing evidence supports an association between sleep quality and risk of dementia. However, little is known about whether objectively measured sleep duration and quality influence cognition in midlife, a period of importance for understanding the direction of the association between sleep and dementia. We examined the association between sleep duration and quality, measured when participants were in their mid-30s to late 40s, and midlife cognition assessed 11 years later among Black and White adults.

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Objective: To examine the association between serum 25-hydroxyvitamin D [25(OH)D] levels and ovarian reserve as measured using antimüllerian hormone (AMH) levels.

Design: Cross-sectional study.

Setting: Detroit, Michigan area.

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Introduction: Higher levels of perceived stress are associated with adverse cardiovascular health. It is plausible that these associations are attenuated among individuals with positive psychological factors such as social support and health-enhancing behaviors. Therefore, this study examined longitudinal associations of chronic stress with cardiovascular disease (CVD) events, and whether social support and physical activity (PA) modify these associations.

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Introduction: Cognitive dysfunction, a leading cause of mortality and morbidity in the USA and globally, has been shown to disproportionately affect the socioeconomically disadvantaged and those who identify as black or Hispanic/Latinx. Poor sleep is strongly associated with the development of vascular and metabolic diseases, which correlate with cognitive dysfunction. Therefore, sleep may contribute to observed disparities in cognitive disorders.

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Cardiovascular-kidney-metabolic health reflects the interplay among metabolic risk factors, chronic kidney disease, and the cardiovascular system and has profound impacts on morbidity and mortality. There are multisystem consequences of poor cardiovascular-kidney-metabolic health, with the most significant clinical impact being the high associated incidence of cardiovascular disease events and cardiovascular mortality. There is a high prevalence of poor cardiovascular-kidney-metabolic health in the population, with a disproportionate burden seen among those with adverse social determinants of health.

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A growing appreciation of the pathophysiological interrelatedness of metabolic risk factors such as obesity and diabetes, chronic kidney disease, and cardiovascular disease has led to the conceptualization of cardiovascular-kidney-metabolic syndrome. The confluence of metabolic risk factors and chronic kidney disease within cardiovascular-kidney-metabolic syndrome is strongly linked to risk for adverse cardiovascular and kidney outcomes. In addition, there are unique management considerations for individuals with established cardiovascular disease and coexisting metabolic risk factors, chronic kidney disease, or both.

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