Publications by authors named "Merce Alemany-Chavarria"
Motivation: Graphical analysis of the molecular structure of proteins can be very complex. Full-atom representations retain most geometric information but are generally crowded, and key structural patterns can be challenging to identify. Non-full-atom representations could be more instructive on physicochemical aspects but be insufficiently detailed regarding shapes (e.
View Article and Find Full Text PDFEpithelial/Mesenchymal (E/M) plasticity plays a fundamental role both in embryogenesis and during tumorigenesis. The receptor for advanced glycation end products (RAGE) is a driver of cell plasticity in fibrotic diseases; however, its role and molecular mechanism in triple-negative breast cancer (TNBC) remains unclear. Here, we demonstrate that RAGE signaling maintains the mesenchymal phenotype of aggressive TNBC cells by enforcing the expression of SNAIL1.
View Article and Find Full Text PDFArticle Synopsis
- Even though immunotherapy is changing how we treat cancer, some patients still have problems because their tumors become resistant.
- Researchers used special antibodies called T cell bispecific antibodies (TCBs) to see how cancer cells react to them, based on the type of tumor antigen they target.
- They found that resistance can happen in different ways: some tumors lose the target protein, while others keep it but change how they respond to immune signals. This information could help make cancer treatments work better and beat resistance.