Acute effect of thymoquinone on action potential and ionic currents of rat cardiac myocytes.

Objectives: This study aims to investigate the acute effects of thymoquinone (TQ) which has been suggested to be a cardioprotective agent, on ventricular myocytes.

Methods: Freshly isolated rat ventricular myocytes were exposed to TQ and using standard whole-cell patch-clamp technique action potential (AP), sodium current (INa), L-type calcium current (ICaL) and transient outward potassium current (Ito) were measured.

Results: TQ prolonged the duration of AP and decreased the peak value compared to that of control myocytes.

Mexiletine-like cellular electrophysiological effects of GS967 in canine ventricular myocardium.

Enhancement of the late Na current (I) increases arrhythmia propensity in the heart, while suppression of the current is antiarrhythmic. GS967 is an agent considered as a selective blocker of I. In the present study, effects of GS967 on I and action potential (AP) morphology were studied in canine ventricular myocytes by using conventional voltage clamp, action potential voltage clamp and sharp microelectrode techniques.

Ellagic Acid Prevents Ca Dysregulation and Improves Functional Abnormalities of Ventricular Myocytes via Attenuation of Oxidative Stress in Pathological Cardiac Hypertrophy.

The aim of this study was to investigate whether ellagic acid (EA) treatment can prevent changes in contractile function and Ca regulation of cardiomyocytes in pathologic cardiac hypertrophy. Groups were assigned as Con group; an ISO group in which the rats received isoproterenol alone (5 mg/kg/day); and an ISO + EA group in which the rats received isoproterenol and EA (20 mg/kg/day) for 4 weeks. Subsequently, fractional shortening, intracellular Ca signals, and L-type Ca currents of isolated ventricular myocytes were recorded.

Rosuvastatin Reduces L-Type Ca Current and Alters Contractile Function in Cardiac Myocytes via Modulation of β-Adrenergic Receptor Signaling.

Rosuvastatin is one of the most used statins to lower plasma cholesterol levels. Although previous studies have reported remarkable cardiovascular effects of rosuvastatin (RSV), the mechanisms of these effects are largely unknown. In this study, we investigated the acute effects of RSV on L-type Ca currents and contractile function of ventricular myocytes under basal conditions and during β-adrenergic stimulation.

The relevance between graft preservation solutions and QTc interval during living donor kidney transplantation and rat cardiomyocytes sampling.

Background: The purpose of the retrospective study was to identify the impacts of different solutions on the electrocardiogram and cardiovascular changes. Moreover, the differences between these solutions were analyzed by examining their impacts on rat ventricular cardiomyocytes.

Methods: Eighty renal transplant patients were evaluated retrospectively.

A novel biomarker for prediction of atrial fibrillation susceptibility in patients with celiac disease.

Background: Celiac disease (CD), a serious autoimmune disorder that occurs in people who are genetically predisposed, is induced by dietary gluten intake and affects primarily the small intestine. Many studies have identified an increased risk of cardiovascular problems in patients with CD. Moreover, these patients are susceptible to certain liver diseases, as well as fibrosis.

Knowledge, attitude and safe behaviour of nurses handling cytotoxic anticancer drugs in Ege University Hospital.

Many antineoplastic drugs are known to be carcinogenic, teratogenic and mutagenic to humans. There is thus a potential risk due to occupational exposure to cytotoxic drugs (CDs). Nurses and pharmacists are the main groups that are exposed to these drugs in the ambulatory care and hospital settings.