Antiracist activism for immigrant rights and healthy coping: Initial evidence for a community-based framework.

Racist and xenophobic policies in the United States (e.g., family separations and lack of access to protected immigration statuses for undocumented immigrants) have historically excluded immigrants of color from accessing full civil rights, thus contributing to widening racial inequities in the US.

Endoscopic repair of duodenal perforations, a scoping review.

Background: There is a discrepancy in the surgical and endoscopic literature for managing duodenal perforations. Although often managed conservatively, surgical repair is the standard treatment for duodenal perforations. This contrasts with the gastroenterology literature, which now recommends endoscopic repair of duodenal perforations, which are more frequently iatrogenic from the growing field of advanced endoscopic procedures.

Effective Radiation Therapy for Isolated Apical Pulmonary Amyloidoma: A Case Report and Treatment Insight.

BACKGROUND Amyloidosis refers to an assortment of diseases characterized by the accumulation and deposition of misfolded proteins in the extracellular matrix of tissues and organs. It may present systemically, affecting multiple organs, or locally by affecting a single organ. When the lungs or mediastinal structures are involved, the term pulmonary amyloid is used.

Mending fragile alliances to fight racism: A developing framework for cross-racial/ethnic solidarity.

In today's sociopolitical climate (e.g., erasure of history, increase in anti-Asian violence, repeal of affirmative action), the fragility of minoritized alliances has become more prominently exposed.

Exploring Potential Ethnic Bias Among MMPI-3 Scales in Assessing Personality Psychopathology.

This study examined statistical bias in the measurement of personality psychopathology in the Latinx population using the Minnesota Multiphasic Personality Inventory-3 (MMPI-3). Data were extracted from two studies that yielded a composite data set of 103 White individuals and 250 Latinx individuals. All participants were administered the MMPI-2-Restructured Form-Extended Battery (MMPI-2-RF-EX) or MMPI-3 and the Personality Inventory for the -5 Short Form (PID-5-SF).

Cultural stress is toxic stress: An expanded cultural stress theory model for understanding mental health risk in Latinx immigrant youth.

Objectives: Latinx immigrant youth are at greater risk for mental health (MH) concerns than their nonimmigrant Latinx peers. Efforts to address mental health disparities have resulted in the much-needed development of theoretical frameworks explaining mental health disparities in marginalized populations. A theoretical framework that is particularly relevant to mental health disparities among Latinx immigrant youth is the Cultural Stress Theory (CST); however, an expansion of this model is necessary to thoroughly describe and explain mental health risk in this population.

Machine Learning for Predictive Analysis of Otolaryngology Residency Letters of Recommendation.

Introduction: Letters of recommendation (LORs) are a highly influential yet subjective and often enigmatic aspect of the residency application process. This study hypothesizes that LORs do contain valuable insights into applicants and can be used to predict outcomes. This pilot study utilizes natural language processing and machine learning (ML) models using LOR text to predict interview invitations for otolaryngology residency applicants.

Impact of bariatric surgery on cytochrome P 450 enzyme activity.

Bariatric surgeries are becoming more prevalent as obesity rates continue to rise. Being that it is an effective weight-loss procedure, it can induce significant anatomical, physiological, and metabolic alterations, which affect the pharmacokinetics of various medications. Cytochrome (CYP) P450 is a group of enzymes that are primarily responsible for metabolizing most medications.

The Psychological Health Symptoms of DACA Recipients: A Systematic Review at the Ten-Year Mark of the Program.

The purpose of this systematic review was to identify the mental health symptoms endorsed by DACA recipients. This study included qualitative and quantitative original, peer-reviewed articles related to mental health or psychological state or wellbeing of DACA recipients. Articles were abstracted from PsychInfo, PubMed, and GoogleScholar.

Cocaine regulates antiretroviral therapy CNS access through pregnane-x receptor-mediated drug transporter and metabolizing enzyme modulation at the blood brain barrier.

Background: Appropriate interactions between antiretroviral therapies (ART) and drug transporters and metabolizing enzymes at the blood brain barrier (BBB) are critical to ensure adequate dosing of the brain to achieve HIV suppression. These proteins are modulated by demographic and lifestyle factors, including substance use. While understudied, illicit substances share drug transport and metabolism pathways with ART, increasing the potential for adverse drug:drug interactions.

Family Separation at the US and Mexico Border Continues.

Record-breaking levels of asylum seeking by families with young children continue at the United States/Mexico border, particularly the Rio Grande Valley sector. In this Commentary, our aim is to increase awareness by providing child and adolescent mental health care providers with an update on current migrant conditions, bringing to light issues of family separation previously highlighted in the Journal. For context, our international group has collected data, via 3 large-scale studies funded by the National Institutes of Health, from more than 600 Latinx immigrants seeking asylum at the US/Mexico border in the last 4 years, during which levels of violence, climate disruption, and poverty in the Northern Triangle of Central America (ie, El Salvador, Guatemala, and Honduras) and Mexico have propelled high and sustained levels of asylum seeking in the United States.

Evaluating SWAG and Its Validity When Compared to 3D Imagery of Secondarily Grafted Cleft Sites.

Objective: To test validity of 2D Standardized Way to Assess Grafts (SWAG) ratings to assess 3D outcomes of bone grafting (ABG).

Patients: 43 patients (34 UCLP, 9 BCLP) with non-syndromic complete clefts, bone-grafted at mean age 9yrs/3mos, with available post-graft occlusal radiographs and cone beam computed tomography (CBCT) (taken mean 4yrs/9mos post-ABG).

Main Outcome Measures: 2D occlusal radiographs rated twice using SWAG by 6 calibrated raters.

An Exploratory Study of Healing Circles as a Strategy to Facilitate Resilience in an Undocumented Community.

Within the United States (U.S.), the COVID-19 pandemic highlighted critical inequalities affecting undocumented communities and resulting in particularly heightened stress for members of these communities.

Mitigation of Nitrogen Mustard-Induced Skin Injury by the -Blocker Carvedilol and Its Enantiomers.

The chemical warfare agent sulfur mustard and its structural analog nitrogen mustard (NM) cause severe vesicating skin injuries. The pathologic mechanisms for the skin injury following mustard exposure are poorly understood; therefore, no effective countermeasure is available. Previous reports demonstrated the protective activity of carvedilol, a US Food and Drug Administration (FDA)-approved -blocker, against UV radiation-induced skin damage.

Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na and K.

Chronic infusion of subpressor level of angiotensin II (ANG II) increases the abundance of Na transporters along the distal nephron, balanced by suppression of Na transporters along the proximal tubule and medullary thick ascending limb (defined as "proximal nephron"), which impacts K handling along the entire renal tubule. The objective of this study was to quantitatively assess the impact of chronic ANG II on the renal handling of Na and K in female rats, using a computational model of the female rat renal tubule. Our results indicate that the downregulation of proximal nephron Na reabsorption (T), which occurs in response to ANG II-triggered hypertension, involves changes in both transporter abundance and trafficking.

Indirect Modulation by FLP-1 Peptides on Chemotaxis and Dispersal Behavior in .

Parasitic nematodes infect and cause morbidity in over one billion people worldwide, with current anthelmintic drugs decreasing in efficacy. To date, nematodes produce more types of neuropeptides than any other animal. We are interested in the role of neuropeptide signaling systems as a possible target for new anthelmintic drugs.

Halo Formation and Resolution at 7-Year Follow-Up After Sacroiliac Joint Fusion Revision: A Case Report.

Case: A 49-year-old woman presented with low back pain after a work-related injury. She failed 5 months of conservative management and subsequently underwent minimally invasive (MI) left sacroiliac joint (SIJ) fusion with 3 triangular titanium implants. Four months postoperatively, she developed recurrence of symptoms and radiographic halo phenomenon about the implants.

Cocaine Regulates Antiretroviral Therapy CNS Access Through Pregnane-X Receptor-Mediated Drug Transporter and Metabolizing Enzyme Modulation at the Blood Brain Barrier.

Background: Appropriate interactions between antiretroviral therapies (ART) and drug transporters and metabolizing enzymes at the blood brain barrier (BBB) are critical to ensure adequate dosing of the brain to achieve HIV suppression. These proteins are modulated by demographic and lifestyle factors, including substance use. While understudied, illicit substances share drug transport and metabolism pathways with ART, increasing the potential for adverse drug:drug interactions.

SLC12A cryo-EM: analysis of relevant ion binding sites, structural domains, and amino acids.

The solute carrier family 12A (SLC12A) superfamily of membrane transporters modulates the movement of cations coupled with chloride across the membrane. In doing so, these cotransporters are involved in numerous aspects of human physiology: cell volume regulation, ion homeostasis, blood pressure regulation, and neurological action potential via intracellular chloride concentration modulation. Their physiological characterization has been largely studied; however, understanding the mechanics of their function and the relevance of structural domains or specific amino acids has been a pending task.