Insulin edema, a little known entity.

Insulin edema is an entity that should be considered in any patient who starts or intensifies an insulin regimen to improve metabolic control. Heart, liver, and kidney problems should always be ruled out beforehand. The exact mechanism is not clear.

Frequency of sensitization to the individual fragrances of fragrance mix I and II according to the factors included in the MOAHLFA index.

Background: Fragrances constitute the second most frequent cause of allergic contact dermatitis in Spain.

Objectives: To determine the rate of sensitization to the individual fragrances of fragrance mix (FM) I and FM II for each of the demographic and clinical factors included in the MOAHLFA (male, occupational dermatitis, atopic dermatitis, hand dermatitis, leg dermatitis, facial dermatitis, age) index.

Methods: We conducted a 5-year retrospective study in 23 Spanish centres.

Automatic incident detection on freeways based on Bluetooth traffic monitoring.

A novel automatic incident detection (AID) method for freeways, based on the use of data provided by Bluetooth sensors and an unsupervised anomaly detection approach, is presented. The two main advantages of the proposed AID system are: (i) the use of Bluetooth sensors offers several practical advantages over inductive loop detectors (ILD), which is one of the preferred sensing technology for traffic flow; and (ii) the unsupervised anomaly detection approach builds a model without the need of incident information. A common problem when designing an AID system is that incident information, i.

Is p-Phenylenediamine Still a Prevalent Contact Allergen in Spain?

Objectives: To analyze trends in the prevalence of contact sensitization to p-phenylenediamine between 2004 and 2014, taking into consideration that the concentration of this product in cosmetics was regulated in 2009. To explore risk factors for contact allergy to p-phenylenediamine.

Material And Methods: Retrospective observational study of patients suspected of having contact dermatitis from allergy to p-phenylenediamine during the years between 2004 and 2015 in 8 tertiary level hospitals.

Sensitization to fragrances in Spain: A 5-year multicentre study (2011-2015).

Background: Fragrance chemicals constitute the second most frequent cause of contact allergy in Spain. There are no data available concerning the individual fragrances that are most frequently involved.

Objectives: To describe the diagnostic contribution provided by specific fragrance series to the results obtained with baseline series fragrance markers by correlating the results of both series.

A PI tuning rule for integrating plus dead time processes with parametric uncertainty.

A novel method to tune a Proportional-Integral (PI) compensator for an integrating plus dead time (IPDT) process, in presence of interval parametric uncertainty, is presented. The design is based on optimization of load disturbance rejection with constraints on the magnitude of the sensitivity and complementary sensitivity functions, that must be satisfied for any element belonging to a set of plants. Instead of solving this problem with a brute force approach (grid the uncertainty set), we prove that this problem can be solved by considering only two plants.

Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC prospective study.

Background: Limonene and linalool are common fragrance terpenes widely used in cosmetic, household and hygiene products. Their primary oxidation products formed after air exposure, the hydroperoxides, have been recognized as important contact haptens.

Objectives: To investigate the prevalence of contact allergy to hydroperoxides of limonene (Lim-OOHs) and hydroperoxides of linalool (Lin-OOHs) in Spain, and to define the optimal concentration for screening in consecutive patients.

Muir-Torre syndrome.

Muir-Torre syndrome (MTS) is an autosomal dominant genodermatosis that consists of unusual cutaneous sebaceous neoplasm, with or without kerathoacantomas and one or more low-grade visceral malignancies, with or without colonic polyps, in the absence of other predisposing factors. This chapter presents a review of the principal clinical and genetic findings in this syndrome and discusses its relation with Lynch syndrome.

[Contact dermatitis due to dimethyl fumarate].

Dimethyl fumarate is a fumaric acid ester. It been used for some years to treat psoriasis and also as a preservative in desiccant sachets in the transport of furniture and footwear. Its irritant properties and sensitizing potential in contact with the skin were recently highlighted when it was implicated as the causative agent in 2 epidemics of severe acute eczema: sofa dermatitis in northern Europe and shoe dermatitis in Spain.

Shoe contact dermatitis from dimethyl fumarate: clinical manifestations, patch test results, chemical analysis, and source of exposure.

Background: The methyl ester form of fumaric acid named dimethyl fumarate (DMF) is an effective mould-growth inhibitor. Its irritating and sensitizing properties were demonstrated in animal models. Recently, DMF has been identified as responsible for furniture contact dermatitis in Europe.

[Clinical follow-up and presence of visceral tumors in 12 patients with sebaceous gland tumors].

Background: Sebaceous gland tumors are a rare type of neoplasm. In some cases they have been associated with visceral tumors in patients with Muir-Torre syndrome, a hereditary form of nonpolyposis colorectal cancer. The aim of this study was to review the diagnosis and follow-up of a series of patients with sebaceous gland tumors to assess how many met the criteria for Muir-Torre syndrome.

Reticular telangiectatic erythema associated with an implantable cardioverter defibrillator.

Reticular telangiectatic erythema (RTE) is a skin reaction associated with implantable cardiac devices (ie, pacemakers and cardioverter defibrillators). We present a patient who developed an erythematous patch over the implantable cardioverter defibrillator site. We discuss the clinical features, histologic findings, and patch testing of this entity.

Genetic studies in variegate porphyria in Spain. Identification of gene mutations and family study for carrier detection.

Background: First, to establish the mutations of the protoporphyrinogen-oxidase (PPOX) gene in four Spanish patients with variegate porphyria (VP). Second, study of carrier status detection in the families, including a four-generation Balearic family. Third, evaluation of the results of carrier detection screening methods.

[Pseudovascular squamous cell carcinoma].

The adenoid form of squamous cell carcinoma is a neoplasm that is characterized by the fact that it presents a pseudoglandular pattern in the histological study. The biological phenomenon that explains this histological pattern is acantholysis; when the latter is massive, the tumor may even mimic a vascular proliferation, and is known as pseudovascular squamous cell carcinoma. This tumor has the clinical characteristics of a squamous cell carcinoma, but histologically, it may mimic an angiosarcoma.

[Nail disorders from epothilone].

We present the cases of two patients diagnosed with non-microcytic lung carcinoma who were treated with epothilone, a new chemotherapeutic agent which disrupts microtubule dynamics. The first one developed nail symptoms consisting of painful nails with a hemorrhagic appearance, which developed into significant structural disorders and onycholysis of all of the fingernails. The patient required antibiotic treatment for the associated paronychia and surgical removal of some of the nails.

Kaposi's varicelliform eruption in an HIV-positive patient after laser resurfacing.

Kaposi's varicelliform eruption (KVE) is an infection produced by the cutaneous dissemination of herpes virus type 1 or 2. Usually this disease has been described in atopic patients. In this report we present an HIV-positive woman with a Kaposi's varicelliform eruption that started after skin resurfacing with a laser.