Activation of an atypical plant NLR with an N-terminal deletion initiates cell death at the vacuole.

Plants evolve nucleotide-binding leucine-rich repeat receptors (NLRs) to induce immunity. Activated coiled-coil (CC) domain containing NLRs (CNLs) oligomerize and form apparent cation channels promoting calcium influx and cell death, with the alpha-1 helix of the individual CC domains penetrating the plasma membranes. Some CNLs are characterized by putative N-myristoylation and S-acylation sites in their CC domain, potentially mediating permanent membrane association.

Kinetic and Computational Studies of CO Oxidation and PROX on Cu/CeO Nanospheres.

Unlabelled: As supported CuO is well-known for low temperature activity, CuO/CeO nanosphere catalysts were synthesized and tested for CO oxidation and preferential oxidation of CO (PROX) in excess H. For the first reaction, ignition was observed at 95 °C, whereas selective PROX occurred in a temperature window from 50 to 100 °C. The catalytic performance was independent of the initial oxidation state of the catalyst (CuO vs.

A first assessment of microplastic contamination in the snow of Ankara, Turkey.

Microplastics (MPs), affecting aquatic and terrestrial ecosystems, have spread globally. The atmosphere is known as a pollutant acceptor and carrier among other ecosystems. However, the fate and amount of microplastics in the atmosphere have been the subject of less research.

Curation of a reference database of COI sequences for insect identification through DNA metabarcoding: COins.

DNA metabarcoding is a widespread approach for the molecular identification of organisms. While the associated wet-lab and data processing procedures are well established and highly efficient, the reference databases for taxonomic assignment can be implemented to improve the accuracy of identifications. Insects are among the organisms for which DNA-based identification is most commonly used; yet, a DNA-metabarcoding reference database specifically curated for their species identification using software requiring local databases is lacking.

Can B-Type Natriuretic Peptide (BNP) Levels Serve as an Early Predictor of Clinical Severity in Patients with COVID-19 Pneumonia?

Background: COVID-19 has continued to aggressively spread and kill. The incidence of complications and associated mortality rates are high. Cardiac damage, which is related to survival, is one of these.

Evaluation of flood risk analyses with AHP, Kriging, and weighted sum models: example of Çapakçur, Yeşilköy, and Yamaç microcatchments.

The present study aims to use the Bingol city center and agricultural plain as a base in future flood management plans and scenarios through flood modeling. In accordance with this purpose, the precipitation map of the catchment was prepared using the Kriging method by assigning values, with the Schreiber formula. Then, the slope, aspect, distance to the stream, land use, geology, soil, and precipitation maps were classified according to the analytical hierarchy process, and consistency indices and consistency ratios were calculated; thus, the factors affecting the flood were ranked as precipitation (CI 0.

Demonstration of the protective effect of ghrelin in the livers of rats with cisplatin toxicity.

Despite the various and newly developed chemotherapeutic agents in recent years, cisplatin is still used very frequently as a chemotherapeutic agent, even though cisplatin has toxic effects on many organs. The aim of our study is to show whether ghrelin reduces the liver toxicity of cisplatin in the rat model. Twenty-eight male Sprague Dawley albino mature rats were chosen to be utilized in the study.

Erythropoietin shows gender dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide induced rat model of autism.

We aimed to evaluate the effects of EPO in the lipopolysaccharide (LPS) induced rat model of autism in terms of social deficits, learning and memory impairments, as well as their neurochemical correlates. Sixteen female Sprague Dawley rats randomly distributed into two equel groups, then were caged with fertile males for mating. At the 10th day of pregnancy, 0.

Neurobehavioral effects of long-term maternal fructose intake in rat offspring.

Background: Previous studies have indicated an association between maternal metabolic conditions and general developmental disturbances of the offspring.

Objective: We aimed to investigate the influence of long-term maternal fructose intake during gestation and lactation on neurobehavioral development of rat offspring.

Methods: Twelve female Sprague Dawley rats were received either 30% fructose enriched water (n = 6) or regular tap water (control, n = 6) for 12 weeks.

Neuroprotective Effects of Eexenatide in a Rotenone-Induced Rat Model of Parkinson's Disease.

Backround: Several studies suggest an association between Parkinson's disease (PD) and type 2 diabetes mellitus; these 2 diseases are both known to affect the common molecular pathways. As a synthetic agonist for the glucagon-like peptide 1 receptor, exenatide has been evaluated as a neuroprotective agent in multiple animal models. Rotenone models of PD have great potential for the investigation of PD pathology and motor and nonmotor symptoms, as well as the role of gene-environment interactions in PD causation and pathogenesis.

Exogenously administered adenosine attenuates renal damage in streptozotocin-induced diabetic rats.

Background: Diabetic nephropathy (DNP) is one of the most serious complications of diabetes mellitus (DM). In the present study, we investigated the potential of adenosine as a therapeutic candidate for preventing DNP.

Methods: Twenty-one adult male rats were included in the study.

The success of the different eradication therapy regimens for Pseudomonas aeruginosa in cystic fibrosis.

What Is Known And Objective: Antibiotic therapy aimed at eradicating Pseudomonas aeruginosa (Pa), and improved regimens to treat chronic Pa infection have played a major role in increasing the median survival of patients with cystic fibrosis (CF). However, different clinical centres use varying eradication regimens. The aim of this study was to evaluate the efficacy of multiple eradication treatments against initial Pa infection and to determine the factors affecting the treatment success.

Beneficial effects of agomelatine in experimental model of sepsis-related acute kidney injury.

Background: Sepsis-related acute kidney injury (AKI) is a serious complication of sepsis. Problems persist regarding early diagnosis and treatment of AKI. The aim of the present study was to evaluate the efficacy of agomelatine, which is primarily known for its positive effects on depressive and anxiety disorders in sepsis-related AKI.

RELATIONSHIP BETWEEN TUBERCULOSIS AND FEMALE HORMONE LEVELS IN POST-MENOPAUSAL WOMEN.

Tuberculosis (TB) is an intracellular infection controlled by T-lymphocyte. After menopause, T-lymphocyte cells counts increase suggesting a possible link between T-lymphocyte cell counts and estrogen and progesterone levels. In this study we compared post-menopausal women with and without TB to determine any differences in estrogen and progesterone levels between the two groups.

Effects of Silk Sericin on Incision Wound Healing in a Dorsal Skin Flap Wound Healing Rat Model.

Background: The wound healing process is complex and still poorly understood. Sericin is a silk protein synthesized by silk worms (Bombyx mori). The objective of this study was to evaluate in vivo wound healing effects of a sericin-containing gel formulation in an incision wound model in rats.

Comparison of blood ethanol stabilities in different storage periods.

Introduction: Measurements of blood ethanol concentrations must be accurate and reliable. The most important factors affecting blood ethanol stability are temperature and storage time. In this study, we aimed to compare ethanol stability in plasma samples at -20 °C for the different storage periods.

Regression of experimental endometriotic implants in a rat model with the angiotensin II receptor blocker losartan.

Aim: Endometriosis is a common disease in women of reproductive age, and many different treatments have been developed, although none has provided a cure. In this study, the efficacy of losartan, an angiotensin II type 1 receptor blocker and an antiangiogenic and anti-inflammatory agent, on regression of experimental endometriotic implants in a rat model was investigated.

Methods: Peritoneal endometriosis was surgically induced in 16 mature female Sprague-Dawley rats.

Number of erythrocyte transfusions is more predictive than serum ferritin in estimation of cardiac iron loading in pediatric patients with acute lymphoblastic leukemia.

Background: Transfusions with packed erythrocytes is a common practice in pediatric patients with acute lymphoblastic leukemia (ALL) who are on chemotherapy. Since there is no physiological excretion mechanism for iron, the iron related to erythrocyte transfusions accumulates and may contribute to late cardiac, hepatic and endocrine complications in these patients.

Procedure: In order to evaluate the iron burden among pediatric patients with ALL and define the risk factors associated with higher iron loading, we evaluated 79 pediatric patients with ALL (36 were off-therapy).

The effects of transport by pneumatic tube system on blood cell count, erythrocyte sedimentation and coagulation tests.

Introduction: Today, the pneumatic tube transport system (PTS) is used frequently because of its advantages related to timing and speed. However, the impact of various types of PTS on blood components is unknown. The aim of this study was to examine the influence of PTS on the quality of routine blood cell counts, erythrocyte sedimentation, and certain blood coagulation tests.

Analysis of fatal cases of pandemic influenza A (H1N1) virus infections in pediatric patients with leukemia.

Background: Pandemic influenza A/H1N1/2009 virus usually causes mild illness in healthy children. Chronic medical conditions are recognized as increasing the risk for complications of influenza virus infection. Although most studies including children with acute leukemia and H1N1 virus have reported no deaths, some anectodal reports with low patient numbers have reported mortality rates as high as 28.

Alkaline phosphatase, cytokeratin 7, cytokeratin 8 in the diagnosis of primary lung adenocarcinoma from 148 pleura fluids specimens.

Adenocarcinomas are the most common cause of malignancy in pleura fluids. Usual primary sites include the lung, breast, gastrointestinal tract, and genitourinary tracts. Predicting the site of origin of an adenocarcinoma can be difficult due to overlapping morphologic characteristics.