Increased keratinocyte activity and PIEZO1 signaling contribute to paclitaxel-induced mechanical hypersensitivity.

Recent work demonstrates that epidermal keratinocytes are critical for normal touch sensation. However, it is unknown whether keratinocytes contribute to touch-evoked pain and hypersensitivity after tissue injury. Here, we used a mouse model of paclitaxel treatment to determine the extent to which keratinocyte activity contributes to the severe neuropathic pain that accompanies chemotherapy.

Physical exercise impacts bone remodeling around bio-resorbable magnesium implants.

Physical exercise has been shown to induce positive reactions in bone healing but next to nothing is known about how it affects the nanostructure, in particular around implants. In this study, we established this link by using small-angle X-ray scattering tensor tomography (SASTT) to investigate nanostructural parameters in 3D such as mineral particle orientation and thickness. As a model system, rat femoral bone with a bio-resorbable implant (ultra-high purity magnesium) was used.

The timing and spatial distribution of mother-offspring interactions in an obligate hider.

Background: Parental care is indispensable for the survival and development of dependent offspring, often requiring a delicate balance of time and energy allocation towards offspring by parents. Among ungulates employing a hider strategy, deciding when and where to provide care while also maintaining a sufficient distance to not reveal the offspring´s hiding place is likely crucial in determining their fate.

Methods: In this study, we analyzed the timing and spatial distribution of mother-offspring interactions in roe deer females (Capreolus capreolus L.

No Future Growth Enhancement Expected at the Northern Edge for European Beech due to Continued Water Limitation.

With ongoing global warming, increasing water deficits promote physiological stress on forest ecosystems with negative impacts on tree growth, vitality, and survival. How individual tree species will react to increased drought stress is therefore a key research question to address for carbon accounting and the development of climate change mitigation strategies. Recent tree-ring studies have shown that trees at higher latitudes will benefit from warmer temperatures, yet this is likely highly species-dependent and less well-known for more temperate tree species.

Rotational dynamics of a disk in a thin film of weakly nematic fluid subject to linear friction.

Dynamics at low Reynolds numbers experiences recent revival in the fields of biophysics and active matter. While in bulk isotropic fluids it is exhaustively studied, this is less so in anisotropic fluids and in confined situations. Here, we combine the latter two by studying the rotation of a disk-like inclusion in a uniaxially anisotropic, globally oriented, incompressible two-dimensional fluid film.

Maximized response by structural optimization of soft elastic composite systems.

Soft actuators triggered in a wire-and contactless way advance soft robotics, for instance, concerning microsurgical perspectives. For optimal performance in this and other contexts, maximized stimuli-responsiveness is frequently desirable. We demonstrate on the example of soft magnetoelastic systems how analytical theoretical measures in combination with computer simulations provide tools to develop optimized components.

The linkage between functional traits and drone-derived phenology of 74 Northern Hemisphere tree species.

Tree phenology is a major component of the global carbon and water cycle, serving as a fingerprint of climate change, and exhibiting significant variability both within and between species. In the emerging field of drone monitoring, it remains unclear whether this phenological variability can be effectively captured across numerous tree species. Additionally, the drivers behind interspecific variations in the phenology of deciduous trees are poorly understood, although they may be linked to plant functional traits.

X-ray tensor tomography for small-grained polycrystals with strong texture.

Small-angle X-ray tensor tomography and the related wide-angle X-ray tensor tomography are X-ray imaging techniques that tomographically reconstruct the anisotropic scattering density of extended samples. In previous studies, these methods have been used to image samples where the scattering density depends slowly on the direction of scattering, typically modeling the directionality, the texture, with a spherical harmonics expansion up until order ℓ = 8 or lower. This study investigates the performance of several established algorithms from small-angle X-ray tensor tomography on samples with a faster variation as a function of scattering direction and compares their expected and achieved performance.

Hydrodynamics of a disk in a thin film of weakly nematic fluid subject to linear friction.

To make progress towards the development of a theory on the motion of inclusions in thin structured films and membranes, we here consider as an initial step a circular disk in a two-dimensional, uniaxially anisotropic fluid layer. We assume overdamped dynamics, incompressibility of the fluid, and global alignment of the axis of anisotropy. Motion within this layer is affected by additional linear friction with the environment, for instance, a supporting substrate.

Phase Separation and Aggregation of α-Synuclein Diverge at Different Salt Conditions.

The coacervation of alpha-synuclein (αSyn) into cytotoxic oligomers and amyloid fibrils are considered pathological hallmarks of Parkinson's disease. While aggregation is central to amyloid diseases, liquid-liquid phase separation (LLPS) and its interplay with aggregation have gained increasing interest. Previous work shows that factors promoting or inhibiting aggregation have similar effects on LLPS.

Internal sites of actuation and activation in thin elastic films and membranes of finite thickness.

Functionalized thin elastic films and membranes frequently feature internal sites of net forces or stresses. These are, for instance, active sites of actuation, or rigid inclusions in a strained membrane that induce counterstress upon externally imposed deformations. We theoretically analyze the geometry of isotropic, flat, thin, linearly elastic films or membranes of finite thickness, laterally extended to infinity.

Evaluating tramway infrastructure on biodiversity and ecosystem services.

Tramways in urban areas for mass transit has been suggested to have a lower environmental footprint than roads. However, studies on the impact of tramways and the surrounding infrastructure on biodiversity is extremely rare despite the potential ecological effects associated with this anthropogenic feature. Surprisingly, we found fewer than 10 papers published on tramway-wildlife interactions, which is significantly lower (vs dozens of thousands) than that of other transportation methods.

Vortex Pattern Stabilization in Thin Films Resulting from Shear Thickening of Active Suspensions.

The need for structuring on micrometer scales is abundant, for example, in view of phononic applications. We here outline a novel approach based on the phenomenon of active turbulence on the mesoscale. As we demonstrate, a shear-thickening carrier fluid of active microswimmers intrinsically stabilizes regular vortex patterns of otherwise turbulent active suspensions.

Revealing legacy effects of extreme droughts on tree growth of oaks across the Northern Hemisphere.

Forests are undergoing increasing risks of drought-induced tree mortality. Species replacement patterns following mortality may have a significant impact on the global carbon cycle. Among major hardwoods, deciduous oaks (Quercus spp.

The Role of Traditional Chinese Medicine and Chinese Pharmacopoeia in the Evaluation and Treatment of COVID-19.

The epidemic prompted by COVID-19 continues to spread, causing a great risk to the general population's safety and health. There are still no drugs capable of curing it. Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are the two other diseases caused by coronaviruses.

Decoding autumn phenology: Unraveling the link between observation methods and detected environmental cues.

Leaf coloring and fall mark the end of the growing season (EOS), playing essential roles in nutrient cycling, resource allocation, ecological interactions, and as climate change indicators. However, understanding future changes in autumn phenology is challenging due to the multitude of likely environmental cues and substantial variations in timing caused by different derivation methods. Yet, it remains unclear whether these two factors are independent or if methodological uncertainties influence the environmental cues determined.

Phase Separation and Aggregation of α-Synuclein Diverge at Different Salt Conditions.

The coacervation and structural rearrangement of the protein alpha-synuclein (αSyn) into cytotoxic oligomers and amyloid fibrils are considered pathological hallmarks of Parkinson's disease. While aggregation is recognized as the key element of amyloid diseases, liquid-liquid phase separation (LLPS) and its interplay with aggregation have gained increasing interest. Previous work showed that factors promoting or inhibiting amyloid formation have similar effects on phase separation.

Genetic and Epigenetic Determinants of COVID-19 Susceptibility: A Systematic Review.

Background: The molecular mechanisms regulating coronavirus pathogenesis are complex, including virus-host interactions associated with replication and innate immune control. However, some genetic and epigenetic conditions associated with comorbidities increase the risk of hospitalization and can prove fatal in infected patients. This systematic review will provide insight into host genetic and epigenetic factors that interfere with COVID-19 expression in light of available evidence.

Stochastic motion under nonlinear friction representing shear thinning.

We study stochastic motion under a nonlinear frictional force that levels off with increasing velocity. Specifically, our frictional force is of the so-called Coulomb-tanh type. At small speed, it increases approximately linearly with velocity, while at large speed, it approaches a constant magnitude, similarly to solid (dry, Coulomb) friction.

Climate change is associated with asynchrony in arrival between two sympatric cuckoos and both host arrival and prey emergence.

Matching the timing of spring arrival to the breeding grounds with hosts and prey is crucial for migratory brood parasites such as cuckoos. Previous studies have focused mostly on phenological mismatch between a single cuckoo species and its hosts but information regarding climate-driven mismatch between multiple sympatric cuckoo species and their hosts and invertebrate prey is still lacking. Here, we analysed long-term data (1988-2023) on the first arrival date of two declining migratory cuckoo species and their 14 migratory host species breeding in sympatry and prey emergence date in Tatarstan (southeast Russia).

Measurement of the retinal venous pressure with a new instrument in patients with primary open angle glaucoma.

Purpose: To compare the results of retinal venous pressure (RVP) measurement performed with contact lens dynamometry (CLD) and with the new IOPstim.

Methods: In this cross-sectional study, we included 36 patients with primary open angle glaucoma with a median age (Q25; Q75) of 74 (64; 77) years (m/f = 18/18), baseline intraocular pressure (IOP): 13.9 (12.

Keratinocyte Piezo1 drives paclitaxel-induced mechanical hypersensitivity.

Recent work demonstrates that epidermal keratinocytes are critical for normal touch sensation. However, it is unknown if keratinocytes contribute to touch evoked pain and hypersensitivity following tissue injury. Here, we used inhibitory optogenetic and chemogenetic techniques to determine the extent to which keratinocyte activity contributes to the severe neuropathic pain that accompanies chemotherapeutic treatment.

GPs' Perspective on a Multimodal Intervention to Enhance Guideline-Adherence in Uncomplicated Urinary Tract Infections: A Qualitative Process Evaluation of the Multicentric RedAres Cluster-Randomised Controlled Trial.

Urinary tract infections (UTIs) are among the most common reasons patients seeking health care and antibiotics to be prescribed in primary care. However, general practitioners' (GPs) guideline adherence is low. The RedAres randomised controlled trial aims to increase guideline adherence by implementing a multimodal intervention consisting of four elements: information on current UTI guidelines (1) and regional resistance data (2); feedback regarding prescribing behaviour (3); and benchmarking compared to peers (4).