Publications by authors named "Menozzi M"
Background: The effectiveness of complete revascularization is well established in patients with ST-segment elevation myocardial infarction (STEMI), but it is less investigated in those with non-ST-segment elevation myocardial infarction (NSTEMI).
Objectives: This study aimed to assess whether complete revascularization, compared with culprit-only revascularization, was associated with consistent outcomes in older patients with STEMI and NSTEMI.
Methods: In the FIRE (Functional Assessment in Elderly MI Patients with Multivessel Disease) trial, 1,445 older patients with myocardial infarction (MI) were randomized to culprit-only or physiology-guided complete revascularization, stratified by STEMI (n = 256 culprit-only vs n = 253 complete) and NSTEMI (n = 469 culprit-only vs n = 467 complete).
Background: The role of quantitative flow ratio (QFR) in the treatment of nonculprit vessels of patients with myocardial infarction (MI) is a topic of ongoing discussion.
Objectives: This study aimed to investigate the predictive capability of QFR for adverse events and its noninferiority compared to wire-based functional assessment in nonculprit vessels of MI patients.
Methods: The FIRE (Functional Assessment in Elderly MI Patients With Multivessel Disease) trial randomized 1,445 older MI patients to culprit-only (n = 725) or physiology-guided complete revascularization (n = 720).
Article Synopsis
- Patients with high bleeding risk (HBR) following a myocardial infarction (MI) face poor outcomes, and it's uncertain if they benefit from complete revascularization.
- The study aimed to compare the outcomes of physiology-guided complete revascularization versus a culprit-only strategy for HBR patients with MI and multivessel disease.
- Results showed that HBR patients had a higher risk of complications, but those who underwent complete revascularization experienced significantly better outcomes, reducing primary endpoint events.
Article Synopsis
- Mortality rates among people with HIV significantly dropped after the introduction of combination antiretroviral therapy, particularly between 1999 and 2009, but remained stable from 2010 to 2020.
- The study analyzed data from over 55,000 participants, revealing that AIDS-related deaths were most common in the earlier period, while deaths from non-AIDS-related malignancies increased in the later years.
- Despite the decline in overall mortality, the reduction was not entirely attributed to better immune function or the presence of other risk factors, suggesting other contributing elements may be at play.
Vergence-Accommodation Conflict: Increased Presbyopia in Virtual Reality.
Klin Monbl Augenheilkd
April 2024
Background: Performance and symptoms in completing a visual search task on a PC monitor and using a head-mounted display (HMD) were compared for different viewing conditions and between users of different ages.
Patients And Methods: Twenty-three young (M = 30 y, SD = 7 y) and 23 older (M = 52 y, SD = 5 y) participants performed a visual search task presented on a PC monitor. The task was repeated using an HMD for a near and a far virtual viewing distance.
Objective: The objectives of this study were to describe the trajectories of bone mineral density (BMD) and trabecular bone score (TBS) changes throughout pre-menopause (reproductive phase and menopausal transition) and post-menopause (early and late menopause) in women with HIV (WWH) undergoing different antiretroviral therapies (ARTs) and explore the risk factors associated with those changes.
Methods: This was an observational longitudinal retrospective study in WWH with a minimum of two DEXA evaluations comprising BMD and TBS measurements, both in the pre-menopausal and post-menopausal periods. Menopause was determined according to the STRAW+10 criteria, comprising four periods: the reproductive period, menopausal transition, and early- and late-menopausal periods.
Article Synopsis
- Patients with atrial fibrillation (AF) undergoing transcatheter aortic valve implantation (TAVI) experience worse short-term outcomes, including higher rates of acute kidney injury and major bleeding compared to those in normal sinus rhythm.
- The study analyzed TAVI patients from 2012 to 2022, focusing on short-term hospital outcomes and long-term effects at an average follow-up of 3.2 years.
- Results showed that both preexisting and new-onset AF increased the risk of all-cause death and hospitalization after TAVI, indicating a significant link between AF and negative health outcomes in this patient group.
Article Synopsis
- * A retrospective case series involving 14 patients treated with dalbavancin revealed a variety of infection types, with a majority caused by Staphylococcus aureus and a clinical success rate of 76.9%, particularly benefiting from TDM guidance.
- * TDM-guided treatment resulted in better clinical outcomes (87.5% success) compared to standard dosing (60% success), highlighting the importance of personalized dosing in managing challenging cardiovascular prosthetic infections.
Background: The aim of this randomized clinical trial (RCT) was to compare immunological changes in virally suppressed people living with HIV (PLWH) switching from a three-drug regimen (3DR) to a two-drug regimen (2DR).
Methods: An open-label, prospective RCT enrolling PLWH receiving a 3DR who switched to bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) or dolutegravir/lamivudine (DTG/3TC) was performed. Blood was taken at baseline and months 6 and 12.
Objectives: We aimed to study whether people living with HIV (PLWH) are at higher risk of in-hospital COVID-19 mortality compared to the general population (GenPop).
Methods: This was a retrospective study in 19 Italian centers (February 2020 to November 2022) including hospitalized PLWH and GenPop with SARS-CoV-2 infection. The main outcome was in-hospital mortality.
Background: We aimed to describe prevalence, incidence, and risk factors for sarcopenic obesity (SO) phenotypes in people living with HIV (PWH) and their association with subclinical cardiovascular disease (CVD).
Methods: Observational, longitudinal study of PWH. A minimum of 1 criterion was necessary to diagnose sarcopenia: weak hand grip (HG), low appendicular skeletal muscle index (ASMI), short physical performance battery (SPPB < 11).
Background: The benefit of complete revascularization in older patients (≥75 years of age) with myocardial infarction and multivessel disease remains unclear.
Methods: In this multicenter, randomized trial, we assigned older patients with myocardial infarction and multivessel disease who were undergoing percutaneous coronary intervention (PCI) of the culprit lesion to receive either physiology-guided complete revascularization of nonculprit lesions or to receive no further revascularization. Functionally significant nonculprit lesions were identified either by pressure wire or angiography.
Aims: To know the prevalence of atrial fibrillation (AF), as well as the incidence of postoperative AF (POAF) in vascular surgery for arterial diseases and its outcome implications.
Methods: We performed a systematic review and meta-analysis following the PRISMA statement.
Results: After the selection process, we analyzed 44 records (30 for the prevalence of AF history and 14 for the incidence of POAF).
Despite cancer being a leading comorbidity amongst individuals with HIV, there are limited data assessing cancer trends across different antiretroviral therapy (ART)-eras. We calculated age-standardised cancer incidence rates (IRs) from 2006-2021 in two international cohort collaborations (D:A:D and RESPOND). Poisson regression was used to assess temporal trends, adjusted for potential confounders.
View Article and Find Full Text PDFVisual attention is crucial to many tasks during working. When it is impaired, the risk of occupational accidents is increased. A potential accident prevention would be the tracking of employees' attentional states to construct break regimes.
View Article and Find Full Text PDFIntroduction: Serum lactate dehydrogenase (LDH) levels are often elevated in cardiovascular diseases. Their prognostic role after subarachnoid hemorrhage (SAH) remains poorly evaluated.
Methods: This is a retrospective single-center study of patients with non-traumatic SAH admitted to the intensive care unit (ICU) of an University Hospital from 2007 to 2022.
Article Synopsis
- Strategies for blood conservation and preoperative assessment can be beneficial for Jehovah's Witness patients undergoing cardiac surgery, necessitating an evaluation of safety and clinical outcomes in these cases.
- A systematic review and meta-analysis of 10 studies involving 2,302 patients indicated no significant differences in short-term mortality between Jehovah's Witness patients and controls after cardiac surgery.
- JW patients demonstrated higher preoperative hemoglobin levels and slightly lower cardiopulmonary bypass times, suggesting that bloodless cardiac surgery can be safe and effective with proper patient management.
Integrase inhibitor (INSTI) use has been associated with greater weight gain (WG) among people living with HIV (PLWH), but it is unclear how this effect compares in magnitude to traditional risk factors for WG. We assessed the population attributable fractions (PAFs) of modifiable lifestyle factors and INSTI regimens in PLWH who experienced a ≥5% WG over follow-up. In an observational cohort study from 2007 to 2019 at Modena HIV Metabolic Clinic, Italy, ART-experienced but INSTI-naive PLWH were grouped as INSTI-switchers vs non-INSTI.
View Article and Find Full Text PDFIntroduction: Young adults with vertical transmission (VT) of human immunodeficiency virus (HIV) represent a fragile population. This study evaluates factors associated with viro-immunological outcome of these patients.
Methods: We performed a multicenter study including HIV-infected subjects with VT ≥ 18 years old from six Italian clinics.
Background: Telemedicine requires either the use of digital tools or a minimum technological knowledge of the patients. Digital health literacy may influence the use of telemedicine in most patients, particularly those with frailty. We aimed to explore the association between frailty, the use of digital tools, and patients' digital health literacy.
View Article and Find Full Text PDFObjectives: Pneumocystis jirovecii pneumonia (PCP) incidence is increasing in people without HIV. Decompensated liver cirrhosis is not currently considered a risk factor for PCP. The aim of this paper is to describe a case series of patients with decompensated liver cirrhosis and PCP.
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- Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a significant threat in healthcare settings, with over a 40% mortality rate among critically ill patients; this review focuses on the best infection prevention and control (IPC) strategies to combat its spread in hospitals.
- A critical review of literature from the past 10 years assessed IPC measures in various settings, with the majority of studies centered on ICU outbreaks, showing high mortality rates up to 50%.
- The review found that while some IPC measures like environmental disinfection were universally applied, others varied significantly by study and setting, emphasizing that targeted 'search and destroy' strategies are key to effective CRAB control.
Article Synopsis
- - The study investigates the link between abacavir (ABC) usage and cardiovascular disease (CVD) among people with HIV, analyzing data from a multinational cohort from 2012 to 2019.
- - Results show that recent ABC users had a higher incidence of CVD events, with the adjusted rate 1.40 times greater compared to non-users, regardless of CVD or chronic kidney disease risk levels.
- - The findings confirm a significant association between recent ABC use and increased CVD incidence, countering the idea that ABC is preferentially given to individuals at higher risk of CVD or chronic kidney disease.
Ventilator-associated pneumonia (VAP) in critically ill patients with COVID-19 represents a very huge global threat due to a higher incidence rate compared to non-COVID-19 patients and almost 50% of the 30-day mortality rate. was the first pathogen involved but uncommon non-fermenter gram-negative organisms such as and have emerged as other potential etiological causes. Against carbapenem-resistant gram-negative microorganisms, Ceftazidime/avibactam (CZA) is considered a first-line option, even more so in case of a ceftolozane/tazobactam resistance or shortage.
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