Publications by authors named "Menon K Divya"

is a traditionally used plant in Ayurvedic and folk medicines. The plant is useful for the management of gastrointestinal diseases as well as skin diseases. In the present study, we analyzed the antitumor potential of in Dalton's lymphoma ascites tumor cells (DLA) and Ehrlich ascites carcinoma (EAC)-induced solid and ascites tumors.

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Objectives: , endemic to Western Ghats of India is pharmacologically similar to and occasionally used as substitute in a well-known Ayurvedic uterine tonic . possess various biological properties, but there are no reports on The present study evaluated the pharmacological properties of and its efficacy in attenuating the sodium fluoride (NaF) induced oxidative stress in mice.

Methods: Antioxidant potential of methanolic extract of .

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Parasporins, a class of non-insecticidal crystal proteins of Bacillus thuringiensis (Bt) are being explored as promising anticancer agents due to their specific toxicity to cancer cells. The present study has identified 25 Bt isolates harbouring parasporin genes from Western Ghats region, the hotspot of biodiversity in India. Among these, the isolate, KAU 41 (Kerala Agricultural University isolate 41) contained non-hemolytic homogenous crystals showing specific cytotoxicity towards cancer cells.

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Context Nutraceuticals possessing antioxidant potential have been used to alleviate side effects exerted by many chemotherapeutics, including cisplatin. Since Apodytes dimidiata E. Mey.

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Context Considering the role of cellular oxidative stress in mutations and subsequent transformation, phytochemicals with antioxidant potential has become a primary choice as chemopreventives. Apodytes dimidiata E. Mey.

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Background: Scutellaria baicalensis is a well-known plant in traditional Chinese medicine. Recently, several Scutellaria species with therapeutic potential have been recognized worldwide. Scutellaria colebrookiana and Scutellaria violacea, native to the Western Ghats of India, are reported to possess free radical scavenging efficacy.

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Article Synopsis
  • Apodytes dimidiata, part of the Icacinaceae family, is known in Zulu traditional medicine for treating inflammation and gastrointestinal issues.
  • The methanolic extract from A. dimidiata leaves showed significant cytotoxic effects against various cancer cell lines, with the most potent active fraction having IC50 values between 0.92 to 3.95 µg/mL.
  • Administration of this active fraction in mice significantly reduced tumor volume by 55.14% and increased lifespan by 44.65%, with the iridoid glycoside genipin identified as the key active component through advanced purification techniques.
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