Publications by authors named "Menna M A Abd El-Mageed"
Article Synopsis
- - The traditional "one drug, one target, one illness" approach has limitations for Alzheimer's disease (AD), prompting researchers to explore multi-target directed ligands (MTDLs) as new therapeutic options.
- - Researchers synthesized new coumarin derivatives and found that compounds 6c and 6h were particularly effective as inhibitors of various targets associated with AD, showing promising results against hAChE, hBuChE, GSK-3β, tau protein, and Aβ aggregation.
- - Compounds 6c and 6h demonstrated superior efficacy compared to the well-known AD medication donepezil, had low cytotoxicity, complied with pharmacokinetic rules, and showed potential for crossing the blood
The novel series of furan-bearing pyrazolo[3,4-b]pyridines were designed as cyclin-dependent kinase 2 (CDK2) inhibitors and as p53-murine double minute 2 (MDM2) inhibitors. The newly synthesized compounds were screened for their antiproliferative activity toward hepatocellular carcinoma (HepG2) and breast cancer (MCF7) cell lines. The most active compounds on both cell lines were additionally evaluated for their in vitro CDK2 inhibitory activity.
View Article and Find Full Text PDFNovel furan 6a-c, furo[2,3-d]pyrimidine 7a-f, 9, 10a-f, 12a,b, 14a-d and furo[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine 8a-f derivatives were designed based on their structural similarity to a previously described oxazole VEGFR-2 back pocket binding fragment. The designed compounds were synthesized and screened for their in vitro VEGFR-2 inhibitory activity where they exhibited good to moderate nanomolar inhibition with improved ligand efficiencies. 8b and 10c (IC = 38.
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