The Effect of Mesenchymal Stem Cell-Enriched Scaffolds on MMP-8 and TGF-β Levels of Vertebrae Postlaminoplasty in Rabbit Model.

Introduction: Some laminoplasty procedures still have restenosis because of bony-bridging failure of the laminar hinge. The present study aimed to determine the effect of mesenchymal stem cell (MSC)-enriched scaffolds on vertebral regeneration after laminoplasty on the basis of the number of osteoblasts, matrix metalloproteinase-8 (MMP-8), and transforming growth factor-beta (TGF-β) levels.

Methods: Laminoplasty procedure using the Hirabayashi technique was conducted at the lumbar level in 32 rabbits that were divided into four and three groups of the control (C) and treatment groups, respectively, with different types of laminoplasty spacer (T1, autograft; T2, scaffold; and T3, scaffold with MSCs).

The Influence of Wharton Jelly Mesenchymal Stem Cell toward Matrix and Synoviocyte Gene Expression on Osteoarthritis.

Background: Therapy for osteoarthritis (OA) with satisfactory results has not been found to date. In OA pathogenesis, gene involved in cartilage degradation and MMP-13 in degrade cartilage, as a member family of NF-κβ genes, serves to modulate inflammatory responses and activates pro-inflammatory cytokines.

Aim: This study aims to identify the influence of Wharton Jelly Mesenchymal Stem Cell (MSC-WJ) on and expression gene in synoviocyte by in vitro.

Analysis of the Relationship between Gene Expression and Gene Expression in Synoviocyte Cells after Mesenchymal Stem Cell Wharton Jelly.

Background: Therapy that can cure osteoarthritis with satisfactory results has not been found to date. In the pathogenesis of osteoarthritis, the genes involved in cartilage degradation include the gene which plays an important role in modulating the occurrence of cartilage damage, which involves activation of pro-inflammatory cytokines. One of the cytokines involved in the cartilage degradation process is Matrix Metalloproteinase (MMP) -13 which is also modulated by NFκβ.

The impact of the International Atomic Energy Agency (IAEA) program on radiation and tissue banking in Indonesia.

In 1986, the National Nuclear Energy Agency (Batan) in Jakarta started the research and development for the setting up of a tissue bank (Batan Research Tissue Bank/BRTB) by preserving fresh amnion or fetal membranes by lyophilisation and then sterilising by gamma irradiation. During the period of 1990 and 2000, three more tissue banks were set up, i.e.