Incidence and prevalence of systemic lupus erythematosus in urban China, 2013-2017: A nationwide population-based study.

Systemic lupus erythematosus (SLE) is becoming a growing public health concern due to increasing disease and economic burdens. Epidemiological information about SLE, especially its incidence rate, is limited in developing countries. In the current study, we sought to investigate the incidence, prevalence, and economic burdens of SLE in urban China.

Temporal and Spatial Variation of Toxic Metal Concentrations in Cultivated Soil in Jiaxing, Zhejiang Province, China: Characteristics and Mechanisms.

The toxic metal (As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn) pollution in 250 agricultural soil samples representing the urban area of Jiaxing was studied to investigate the temporal and spatial variations. Compared to the early 1990s, the pollution level has increased. Industry and urbanization were the main factors causing toxic metal pollution on temporal variation, especially the use of feed containing toxic metals.

Assessing Pb-Cr Pollution Thresholds for Ecological Risk and Potential Health Risk in Selected Several Kinds of Rice.

The expected typical gley moist paddy soil was collected in Zhejiang Province, China, and conventional (XS 134 and JH 218) and varieties of hybrid (YY 538 and CY 84) rices were used for a pot experiment. The effects of exogenous heavy metals lead (Pb) and chromium (Cr) on rice growth and the accumulation of heavy metals in the grains were studied. The results show that heavy metal concentrations in soil and rice grains have significant correlations, and Pb and Cr significantly (p < 0.

Association of IL-10 and IL-10RA single nucleotide polymorphisms with the responsiveness to HBV vaccination in Chinese infants of HBsAg(+)/HBeAg(-) mothers: a nested case-control study.

Objectives: To investigate the association of interleukin (IL)-10 and IL-10 receptor A (IL-10RA) single nucleotide polymorphisms with the responsiveness to hepatitis B virus (HBV) vaccination in newborns whose mothers were hepatitis B surface antigen (HBsAg)(+)/hepatitis B e antigen (HBeAg)(-).

Design: Nested case-control study.

Setting: Changchun, China.

20 μg hepatitis B vaccination reduced the risk of low responsiveness in infants with HLA-II risk genotype of HBsAg positive mothers.

Infants born to HBV carrier mothers are persistently at a higher risk for HBV infection. We investigated the association between HLA SNPs and low responsiveness to HBV vaccination, and the differences of immune response in carriers of risk genotypes who received different doses of the vaccination. 1040 infants from the prevention of mother-to-infant transmission of HBV cohort were included.

Rolling-circle replication initiation protein of haloarchaeal sphaerolipovirus SNJ1 is homologous to bacterial transposases of the IS family insertion sequences.

For most archaeal viruses, the mechanisms of genome replication are poorly understood, while the nature and provenance of their replication proteins are usually unknown. Here we show that replication of the circular double-stranded DNA genome of the halophilic virus SNJ1, a member of the family , is associated with the accumulation of single-stranded replicative intermediates, which is typical of rolling-circle replication. The homologues of RepA, the only enzyme that is indispensable for SNJ1 genome replication, are widespread in archaea and are most closely related to bacterial transposases of the IS and IS family insertion sequences, as opposed to other viral rolling-circle replication initiation proteins.

Construction of Expression Shuttle Vectors for the Haloarchaeon sp. J7 Based on Its Chromosomal Origins of Replication.

Haloarchaeon sp. J7, the first reported archaeon harboring both plasmid and chromosome-based temperate viruses, is a useful model for investigating archaeal virus-host and virus-virus interactions. However, the lack of genetic tools has limited such studies.