Impacts of MTBE in gasoline on the tailpipe ammonia emissions from China-6 certified passenger vehicles.

Postcatalyst ammonia emissions from gasoline vehicles recently received attentions because of their contribution to the formation of urban secondary aerosols. To better understand whether fuel formulation would curb ammonia, the influence of methyl tertiary-butyl ether (MTBE) additive in gasoline on the tailpipe ammonia emissions from six China-6 compliant vehicles was investigated over the World Harmonized Light-duty Test Cycle (WLTC) at -7 °C and 23 °C. Ammonia emissions were measured with MTBE-free and 10 % MTBE-containing China-6 compliant gasoline fuels on the test vehicles.

VOC species emissions from gasoline direct injection (GDI) and port fuel injection (PFI) vehicles combusting different gasoline.

Reducing VOCs can effectively reduce the concentration of PM and O. Different gasoline compositions can impact the VOC species emitted by GDI and PFI vehicles. In this study, VOC species emitted from GDI and PFI vehicles combusting gasoline with different compositions (i.

Pilot analysis of tire tread characteristics and associated tire-wear particles in vehicles produced across distinct time periods.

Owing to stringent vehicle emission regulations and the shifting automotive landscape towards clean-energy vehicles, the emission of non-exhaust tire-wear particles and its implications for microplastic contamination have garnered substantial attention, emerging as a focal point of research interest. Unlike traditional source apportionment methods involving direct environmental sampling, this study focuses on the physical and chemical attributes of tire treads, the tread temperature changes, and the tire-wear particle emissions of three light-duty vehicles manufactured between 2011 and 2021. This study advances the understanding of the effects of tire properties on particle emissions, which provides preliminary information on low-wear tires.

Causal association between rheumatoid arthritis and an increased risk of age-related macular degeneration: A Mendelian randomization study.

This study's goal is to evaluate if there is a causal connection between rheumatoid arthritis (RA) and age-related macular degeneration (AMD), despite past epidemiological studies suggesting an association between the 2 disorders. The impact of RA on AMD is still unknown. Mendelian randomization (MR) was utilized in this study to assess the two-sample causal relationship between RA and AMD.

Integrative omics analysis elucidates the genetic basis underlying seed weight and oil content in soybean.

Synergistic optimization of key agronomic traits by traditional breeding has dramatically enhanced crop productivity in the past decades. However, the genetic basis underlying coordinated regulation of yield- and quality-related traits remains poorly understood. Here, we dissected the genetic architectures of seed weight and oil content by combining genome-wide association studies (GWAS) and transcriptome-wide association studies (TWAS) using 421 soybean (Glycine max) accessions.

A quaternary ammonium-based nanosystem enables delivery of CRISPR/Cas9 for cancer therapy.

Genome editing mediated by CRISPR/Cas9 is an attractive weapon for cancer therapy. However, delivery of CRISPR/Cas9 components to achieve therapeutic efficiency is still challenging. Herein, a quaternary ammonium-functionalized poly(L-lysine) and a cholesterol-modified PEG (QNP) were self-assembled with a negatively charged CRISPR Cas9/sgRNA ribonucleoprotein (RNP) to form a ternary complex (QNP/RNP).

Policy instruments facilitate China's COVID-19 work resumption.

Governments worldwide have announced stimulus packages to remobilize the labor force after COVID-19 and therefore to cope with the COVID-19-related recession. However, it is still unclear how to facilitate large-scale work resumption. This paper aims to clarify the issue by analyzing the large-scale prefecture-level dataset of human mobility trajectory information for 320 million workers and about 500,000 policy documents in China.

Comparison of tailpipe carbonyls and volatile organic compounds emissions from in-use gasoline/CNG bi-fuel vehicles.

Ground-level ozone contamination has been globally an urban air quality issue, particularly for China, which has recently made significant progress in purifying its sky. Unregulated exhaust emissions from motor vehicles, predominantly carbonyls and volatile organic compounds (VOCs), are among the leading contributors to ozone formation. In this chassis-level study, the unregulated emissions from five China-5 certified gasoline/CNG bi-fuel taxis, along with their ozone forming potential (OFP), were evaluated.

Exosome-mediated delivery of superoxide dismutase for anti-aging studies in Caenorhabditis elegans.

Aging is a dynamic and progressive process mediated by reactive oxygen species (ROS), and the antioxidant enzyme superoxide dismutase (SOD) can effectively scavenge ROS to extend longevity. However, the instability and impermeability of native enzyme limit its in vivo biomedical application. Currently, exosome as protein carriers attracts considerable attention in the disease treatment owing to low immunogenicity and high stability.

Responses of bacterial community and N-cycling functions stability to different wetting-drying alternation frequencies in a riparian zone.

Wetting-drying alternation (WD) of the soil is one of the key characteristics of riparian zones shaped by dam construction, profoundly impacting the soil microenvironment that determines the bacterial community. Knowledge concerning the stability of bacterial community and N-cycling functions in response to different frequencies of WD remains unclear. In this study, samples were taken from a riparian zone in the Three Gorges Reservoir (TGR) and an incubation experiment was conducted including four treatments: constant flooding (W), varied wetting-drying alternation frequencies (WD1 and WD2), and constant drying (D) (simulating water level of 145 m, 155 m, 165 m, and 175 m in the riparian zone respectively).

Brain functional specialization in obsessive-compulsive disorder associated with neurotransmitter profiles.

Background: Cerebral specialization is an important functional architecture of the human brain. Abnormal cerebral specialization may be the underlying pathogenesis of obsessive-compulsive disorder (OCD). Resting-state functional magnetic resonance imaging (rs-fMRI) was used to show that the specialization pattern of OCD was of great significance for early warning and precise intervention of the disease.

Gram-scale preparation of quercetin supramolecular nanoribbons for intestinal inflammatory diseases by oral administration.

Gastrointestinal (GI) tract, which possesses the largest surface area of mucosa in the body, is easily suffered from inflammatory damages under the exposure of external stimulations. Excessive reactive oxygen species (ROS) production and continuous oxidative stress in intestines can elicit local mucosal injury, accelerate mucosal ulceration, and amplify the inflammatory response. Thereby, antioxidant therapy is a potential strategy against intestinal inflammatory diseases.

Correction: Zhang et al. The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis. . 2022, , 786.

In the original article [...

The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis.

(1) Background: Emotion regulation (ER) is regarded as a core treatment target for depression and other mental illnesses. In recent years, non-invasive brain stimulation (NIBS) has been extensively used as an intervention for mental illnesses, but there has been no systematic review conducted regarding its effect on emotion regulation. Therefore, we conducted a meta-analysis of the effectiveness of NIBS for emotion regulation; (2) Methods: Systematic searches were conducted in Embase, Web of Science, PubMed, and Cochrane Library.

Multi-analytical approach to the mural painting from an ancient tomb of Ming Dynasty in Jiyuan, China: Characterization of materials and techniques.

The pigments, surface deposition, preparatory layer and support from a mural painting tomb of Ming Dynasty (1368-1644 CE) were first time analyzed by micro-Raman, Fourier-transform Infrared (FT-IR), X-ray diffraction (XRD), scanning electron microscope with energy-dispersive X-ray microanalysis (SEM-EDX), thermogravimetry and differential scanning calorimetry (TG-DSC) to reach a better understanding of the composition of the materials and the techniques adopted. All the pigments were identified, including hematite, cinnabar, malachite, yellow ochre, calcite and carbon black. The preparatory layer was found to be prepared by fine lime mortar with cotton fiber inside.

A carrier-free photodynamic nanodrug to enable regulation of dendritic cells for boosting cancer immunotherapy.

Immune response is initiated by dendritic cells (DCs), where the cross-presentation of antigens by DCs determines the activating of cytotoxic T cells. However, the efficacy of DCs-initiated immune response is governed by multiple (cascade) steps of immunogenic cell death (ICD), recruitment of DCs, and cross-presentation of DCs. It is urgent but challenging to achieve a platform for simultaneously regulating these multiple steps, amplifying the immune response against tumors.

Boosting the Ion Mobility in Solid Polymer Electrolytes Using Hollow Polymer Nanospheres as an Additive.

Solid polymer electrolytes (SPEs) possess improved thermal and mechanical stability as safe energy storage devices. However, their low ion mobilities and poor electrochemical stabilities still hinder the wide industrial application of SPEs. Herein, we introduce an SPE design that provides an enormous number of electrochemically stable pathways and space for lithium-ion transport, blending polymer (polydopamine) hollow nanospheres with an inactive inorganic template into a poly(ethylene oxide) (PEO) and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) based SPE.

Evaporative emission characteristics of high-mileage gasoline vehicles.

Evaporative emissions of vehicles are an essential source of atmospheric volatile organic compounds (VOCs), contributing to ozone contamination, especially in urban areas. Due to the outdated standards under which in-use vehicles were constructed and the ageing of control devices, high-mileage vehicles tend to produce an enormous amount of evaporative emissions. In this study, evaporative emissions from two high-mileage light-duty gasoline vehicles were quantified using VT-SHED, and their ozone-forming potential (OFP) values were calculated based on the identified VOC species.

A self-amplifying nanodrug to manipulate the Janus-faced nature of ferroptosis for tumor therapy.

Ferroptosis, an unusual non-apoptotic cell death caused by the iron-dependent accumulation of lipid peroxide, enables the flexible design of an antitumor platform. Specifically, as a positive role, ferroptosis can induce an immune response accompanied with the interferon-γ (IFN-γ)-triggered disruption of the glutathione peroxidase 4 pathway for cascade enhancement of ferroptotic cell death and ferroptosis-induced immunotherapeutic efficacy. However, as a negative role, ferroptosis also triggers inflammation-associated immunosuppression by up-regulation of the cyclooxygenase-2/prostaglandin E pathway and IFN-γ-associated adaptive immune resistance by up-regulation of programmed death ligand-1 (PD-L1), impeding the antitumor efficacy of multiple immune cells by immune escape.

Development of an in vitro carcinogenesis model of human papillomavirus-induced cervical adenocarcinoma.

Cervical adenocarcinoma (ADC) is the second most common pathological subtype of cervical cancer after squamous cell carcinoma. It accounts for approximately 20% of cervical cancers, and the incidence has increased in the past few decades, particularly among young patients. The persistent infection of high-risk human papillomavirus (HPV) is responsible for most cervical ADC.

A heme-regulatable chemodynamic nanodrug harnessing transcription factor Bach1 against lung cancer metastasis.

Non-small cell lung cancer (NSCLC) is a type of cancer dominated by metastasis-induced death. The transcription factor BTB and CNC homology 1 (Bach1) regulates almost all metastasis steps by activating the transcription of critical metastatic genes. It is urgent to engineer a nanodrug enabling regulation of Bach1 against tumor metastasis.

A mitochondrial-metabolism-regulatable carrier-free nanodrug to amplify the sensitivity of photothermal therapy.

The oxidative phosphorylation inhibitor atovaquone (ATO) and the photosensitizer new indocyanine green (IR820) were self-assembled into carrier-free nanodrugs (IR820/ATO NPs) to achieve superior photothermal therapy (PTT), offering an attractive mitochondrial metabolism-regulatable approach for breast cancer treatment, where adenosine triphosphate (ATP) was downregulated along with downregulating the expression of heat shock proteins (HSPs) to amplify the sensitivity of PTT.

Platelet-armored nanoplatform to harmonize janus-faced IFN-γ against tumor recurrence and metastasis.

Interferon-γ (IFN-γ) plays contradictory roles in tumor immunology: (I) to activate positive host's immunity for eliminating tumor; (II) to induce negative adaptive immune resistance via up-regulating programmed death ligand-1 (PD-L1) expression for tumors to evade immune surveillance. The negative feedback loop between the IFN-γ recovery and the IFN-γ-induced PD-L1 up-regulation puts postoperative adjuvant chemotherapy into a dilemma. It is of great significance but challenging to manipulate the double-edge effects of IFN-γ against postoperative tumor progression.