The current clinical landscape of preterm infants less than 32 weeks of gestation receiving delivery room chest compression in Jiangsu Province, China.

Objective: To provide an updated review of the clinical profile and outcomes of delivery room chest compression (DR-CC) in China.

Method: Retrospective analysis of prospectively collected data from 23 neonatal intensive care units in Jiangsu, China (2019-2021). Antepartum, delivery room, and postpartum variables in DR-CC-receiving and no-DR-CC groups were compared using uni- and multivariate analyses.

Biotransformation of minocycline by a novel strain Kluyvera sp. DM13 isolated from municipal sludge: Performances, removal pathways, and toxicity.

Minocycline has been widely used in clinical treatment and its residues were considered to have environmental safety risks due to complex chemical structure. Therefore, it is necessary to find an efficient and environmentally friendly method to remove minocycline from the environment. This study screened and isolated a minocycline degrading strain DM13 from the activated sludge for municipal sewage pipeline, and optimized the biodegradation of minocycline by DM13 under various environmental conditions.

Simultaneous degradation of roxithromycin and nitrogen removal by Acinetobacter pittii TR1: Performances, pathways, and mechanisms.

Pharmaceutical and aquaculture wastewater contains not only antibiotics but also high concentrations of nitrogen, but few studies have been conducted on bacteria that target this complex pollution for degradation. A novel heterotrophic nitrifying aerobic denitrifying (HN-AD) strain Acinetobacter pittii TR1 isolated from soil. When the C/N ratio was 20, the strain could degrade 50 mg/L roxithromycin (ROX) and the nitrogen removal rate was 96.

Attempts to obtain clean biochar from hyperaccumulator through pyrolysis: Removal of heavy metals and transformation of phosphorus.

The sound disposal of the ensuing heavy metal-rich plants can address the aftermath of phytoremediation. In this study, the first attempt was made to obtain heavy metals-free and phosphorus-rich biochar from phytoremediation residue (PR) by pyrolysis, and the effects of chlorinating agent type, chlorine dosage, and pyrolysis residence time on heavy metal removal, phosphorus (P) transformation, and biochar properties were investigated. The results showed that as chlorine dosage and pyrolysis residence time increased, added polyvinyl chloride (PVC) reduced the concentration of Zn in biochar to one-tenth of that in PR by intensified chlorination, where both Zn concentration (2727.

Effect of NaCl on the migration of heavy metals during the non-isothermal and isothermal combustion of sludge: Static and dynamic analyses.

Chlorine has been proven to promote the volatilization of heavy metals during sludge combustion. This work compared the migration of heavy metals with NaCl addition under different combustion modes at 900 ℃. The combustion modes have less effect on the mineral phase of residues, but the volatilization and toxicity reduction of heavy metals were more pronounced under isothermal combustion.

Insight into the role of SO on selenium conversion during adsorption by CaO: Theoretical calculation and experimental study.

SO can noticeably impact the control of high toxic selenium emissions from flue gas by CaO. Surprisingly, our experiments showed that under certain conditions, SO can promote selenium capture by CaO, rather than hinder it. To elucidate the underlying mechanism, a combination of theoretical calculations and experiments was conducted.

A non-invasive strategy for suppressing asthmatic airway inflammation and remodeling: Inhalation of nebulized hypoxic hUCMSC-derived extracellular vesicles.

Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are extremely promising nanoscale cell-free therapeutic agents. We previously identified that intravenous administration (IV) of human umbilical cord MSC-EVs (hUCMSC-EVs), especially hypoxic hUCMSC-EVs (Hypo-EVs), could suppress allergic airway inflammation and remodeling. Here, we further investigated the therapeutic effects of Hypo-EVs administration by atomizing inhalation (INH), which is a non-invasive and efficient drug delivery method for lung diseases.

Improved adsorption capacity and applicable temperature of gaseous PbCl capture by modified montmorillonite with combined thermal treatment and acid activation.

The emission of semi-volatile heavy metals during the thermal utilization of various fuels has been a huge threat to the environment. In this study, the montmorillonite modified by thermal treatment and hydrochloric acid activation was evaluated for the PbCl adsorption performance. The optimum adsorption temperature of sorbents increased with the thermal treatment temperature (<500 °C) for the increased amount of reactive sites caused by the removal of interlayer water and hydroxyl, while a higher treatment temperature will collapse the lamellar structure of montmorillonite and greatly inhibit the PbCl adsorption.

Experimental and theoretical studies on the adsorption characteristics of Si/Al-based adsorbents for lead and cadmium in incineration flue gas.

Si/Al-based adsorbents are effective adsorbents for capturing heavy metals in incineration flue gases at high temperatures in the furnace. In this work, the adsorption characteristics and adsorption mechanisms of Si/Al-based adsorbents for lead and cadmium vapors were studied using a combination of experimental and density functional theory (DFT) calculations. The trapping performance of a series of Si/Al-based adsorbents for Pb and Cd vapors was investigated using a self-designed gas-solid two-phase rapid adsorption experimental system.

Efficient contour-based annotation by iterative deep learning for organ segmentation from volumetric medical images.

Purpose: Training deep neural networks usually require a large number of human-annotated data. For organ segmentation from volumetric medical images, human annotation is tedious and inefficient. To save human labour and to accelerate the training process, the strategy of annotation by iterative deep learning recently becomes popular in the research community.

Effect of CaO and montmorillonite additive on heavy metals behavior and environmental risk during sludge combustion.

Serious pollution is caused by heavy metals (HMs) emission during sludge combustion treatment, but the addition of minerals has the ability to alleviate the migration of HMs to the gaseous state. In this study, HMs (As, Cr, Zn and Cu) behavior, speciation, and environmental risk during sludge combustion with CaO and montmorillonite (MMT) additive was investigated in the lab-scale tube furnace. The results showed that the sludge combustion was mainly determined by volatile matter.

AnatomySketch: An Extensible Open-Source Software Platform for Medical Image Analysis Algorithm Development.

The development of medical image analysis algorithm is a complex process including the multiple sub-steps of model training, data visualization, human-computer interaction and graphical user interface (GUI) construction. To accelerate the development process, algorithm developers need a software tool to assist with all the sub-steps so that they can focus on the core function implementation. Especially, for the development of deep learning (DL) algorithms, a software tool supporting training data annotation and GUI construction is highly desired.

Clinical effect of different maintenance doses of caffeine citrate in the treatment of preterm infants requiring assisted ventilation: a pilot multicenter study.

Objectives: To explore the optimal maintenance dose of caffeine citrate for preterm infants requiring assisted ventilation and caffeine citrate treatment.

Methods: A retrospective analysis was performed on the medical data of 566 preterm infants (gestational age ≤34 weeks) who were treated and required assisted ventilation and caffeine citrate treatment in the neonatal intensive care unit of 30 tertiary hospitals in Jiangsu Province of China between January 1 and December 31, 2019. The 405 preterm infants receiving high-dose (10 mg/kg per day) caffeine citrate after a loading dose of 20 mg/kg within 24 hours after birth were enrolled as the high-dose group.

Regression analysis of multivariate interval-censored failure time data with informative censoring.

Regression analysis of multivariate interval-censored failure time data has been discussed by many authors. For most of the existing methods, however, one limitation is that they only apply to the situation where the censoring is non-informative or the failure time of interest is independent of the censoring mechanism. It is apparent that this may not be true sometimes and as pointed out by some authors, the analysis that does not take the dependent censoring into account could lead to biased or misleading results.

Transformation of Cr under sintering of Ca-rich solid waste with kaolin: Analysis of multi-element coupled interactions.

The high toxicity of Cr-Ca compounds generated during the heat treatment of solid waste will heavily threat the environment. In this work, a kind of Ca-rich river sludge which is bound with Ca and heavy metals was combusted with kaolin under 900 °C for 3 h in a muffle to study the transformation of Cr. The effects of kaolin on Cr transformation were investigated through sequential extraction, the risk assessment of heavy metals, and constant pH leaching test, also combined with crystal phase analysis of Ca-Al-Si minerals.

Synthesis of cinnamoyl glucoside derivatives and their antiproliferation activities against murine melanoma B16-F10 cell line.

Twelve cinnamoyl glucoside derivatives were prepared by glycosylation of glucosyl trichloroacetimidate and cinnamic acid derivatives, followed by dechloroacetylation with a pyridine/HO mixture. Their structures were characterized by H and C NMR, as well as mass analysis. All the products were tested for their antiproliferation activities against murine melanoma B16-F10 cell line.

Two new iridoid glycosides from Gardeniae Fructus.

Two new iridoid glycosides, genipin 1,10-di-O-α-l-rhamnoside (1) and genipin 1,10-di-O-β-d-xylopyranoside (2), along with thirteen known compounds (3-15) were isolated from Gardeniae Fructus. Their structures were elucidated by physical data analyses such as NMR, UV, IR, HR-ESI-MS, as well as chemical hydrolysis. All compounds were tested for their tyrosinase inhibitory and antioxidant activities.

Green production of a novel sorbent from kaolin for capturing gaseous PbCl in a furnace.

The pollution of semi-volatile heavy metals is one of the key environmental risks for municipal solid waste incineration, and in-situ adsorption of metals within the furnace by mineral sorbents such as kaolin has been demonstrated as a promising emission control method. To lessen the consumption of sorbent, a novel material of amorphous silicate was produced from kaolin through pressurised hydrothermal treatment. Its performance of gaseous PbCl capture was tested in a fixed bed furnace and compared with unmodified kaolin and metakaolin.

Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma.

Asthma is a complex and heterogeneous inflammatory response characterized by various immune cells, including myeloid-derived suppressor cells (MDSCs) and CD4 T-cell subsets. However, few studies on MDSC subsets and the association between MDSCs and CD4 T-cell subsets in asthma are reported. In the present study, we detected CD4 T cells and MDSC subsets and evaluated the relationship of these cells in mice with ovalbumin-induced asthma.

Schistosoma japonicum peptide SJMHE1 suppresses airway inflammation of allergic asthma in mice.

Helminths and their products can shape immune responses by modulating immune cells, which are dysfunctional in inflammatory diseases such as asthma. We previously identified SJMHE1, a small molecule peptide from the HSP60 protein of Schistosoma japonicum. SJMHE1 can inhibit delayed-type hypersensitivity and collagen-induced arthritis in mice.