Publications by authors named "Mengzhen Su"
Article Synopsis
- Scientists studied a special part of the coronavirus called the spike protein, which changes over time and affects how our bodies fight the virus with antibodies.
- They found an antibody called D1F6 that works really well against many new versions of the virus, including a recent one called XBB.1.5.
- Some changes in the virus's spike protein can make it harder for D1F6 to work, but several changes together can block it much better, showing how the virus can avoid being attacked by our immune defenses.
SARS-CoV-2 Omicron variants feature highly mutated spike proteins with extraordinary abilities in evading antibodies isolated earlier in the pandemic. Investigation of memory B cells from patients primarily with breakthrough infections with the Delta variant enables isolation of a number of neutralizing antibodies cross-reactive to heterologous variants of concern (VOCs) including Omicron variants (BA.1-BA.
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