Correction: Revealing nuclear receptor hub modules from Basal-like breast cancer expression networks.

[This corrects the article DOI: 10.1371/journal.pone.

Brain-Controlled Hand Exoskeleton Based on Augmented Reality-Fused Stimulus Paradigm.

Advancements in brain-machine interfaces (BMIs) have led to the development of novel rehabilitation training methods for people with impaired hand function. However, contemporary hand exoskeleton systems predominantly adopt passive control methods, leading to low system performance. In this work, an active brain-controlled hand exoskeleton system is proposed that uses a novel augmented reality-fused stimulus (AR-FS) paradigm as a human-machine interface, which enables users to actively control their fingers to move.

Diversity of CFTR variants across ancestries characterized using 454,727 UK biobank whole exome sequences.

Background: Limited understanding of the diversity of variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene across ancestries hampers efforts to advance molecular diagnosis of cystic fibrosis (CF). The consequences pose a risk of delayed diagnoses and subsequently worsened health outcomes for patients. Therefore, characterizing the spectrum of CFTR variants across ancestries is critical for revolutionizing molecular diagnoses of CF.

Lipidomic and transcriptomic analysis of the increase in eicosapentaenoic acid under cobalamin deficiency of Schizochytrium sp.

Schizochytrium sp. is a heterotrophic microorganism capable of accumulating polyunsaturated fatty acids and has achieved industrial production of docosahexaenoic acid (DHA). It also has the potential for eicosapentaenoic acid (EPA) production.

Macrophage β-arrestin-1 deteriorates DSS-induced colitis through interaction with NF-κB signaling.

β-arrestin-1 has been demonstrated to participate in the regulation of inflammatory reactions in several diseases. Thus, this study aimed to investigate the role of macrophage β-arrestin-1 in the pathogenesis and progression of ulcerative colitis (UC). A myeloid β-arrestin-1 conditional knockout mouse model was generated to explore the role of macrophage β-arrestin-1.

Combined administration of anisodamine and neostigmine alleviated colitis by inducing autophagy and inhibiting inflammation.

Our previous work demonstrated that the anisodamine (ANI) and neostigmine (NEO) combination produced an antiseptic shock effect and rescued acute lethal crush syndrome by activating the α7 nicotinic acetylcholine receptor (α7nAChR). This study documents the therapeutic effect and underlying mechanisms of the ANI/NEO combination in dextran sulfate sodium (DSS)-induced colitis. Treating mice with ANI and NEO at a ratio of 500:1 alleviated the DSS-induced colitis symptoms, reduced body weight loss, improved the disease activity index, enhanced colon length, and alleviated colon inflammation.

ZjWRKY23 and ZjWRKY40 Promote Fruit Size Enlargement by Targeting and Downregulating Expression in Chinese Jujube.

Fruit size is crucial for fruit trees, as it contributes to both quality and yield. However, the underlying mechanism of fruit size regulation remains largely unknown. Taking advantage of using a fruit double-sized bud mutant of Chinese jujube, "Jinkuiwang" and its wild type, "Jinsixiaozao", we carried out a comprehensive study on the mechanism of fruit size development in jujube.

Depletion of β-arrestin-1 in macrophages enhances atherosclerosis in ApoE mice.

Autophagy in atherosclerotic plaque macrophage contributes to the alleviation of atherosclerosis through the promotion of lipid metabolism. β-arrestins are multifunctional proteins participating various kinds of cellular signaling pathways. Here we aimed to determine the role of β-arrestin-1, an important member of β-arrestin family, in atherosclerosis, and whether autophagy was involved in this process.

Si-Ni-San Ameliorates the Clinical Symptoms of Interstitial Cystitis/Bladder Pain Syndrome in Rats by Decreasing the Expression of Inflammatory Factors.

Objective: To observe the therapeutic effect of Si-Ni-San (SNS) on interstitial cystitis/bladder pain syndrome (IC/BPS) in rats, and explore the possible regulatory mechanism of SNS on IC/BPS combined with transcriptome analysis.

Methods: An IC/BPS model of Sprague-Dawley (SD) rats was established with cyclophosphamide (CYP), and the SNS was extracted for treatment. The rats were divided into 4 groups (n = 10 in each group): Control group (blank), cyclophosphamide group (CYP group, CYP injection + normal saline gavage), lower-dose SNS group (LSNS group, CYP injection + 6 g/kg SNS gavage), and higher-dose SNS group (HSNS group, CYP injection + 12 g/kg SNS gavage).

Integration of Physiological, Transcriptomic and Metabolomic Reveals Molecular Mechanism of Response to Zn Stress.

Utilizing mycoremediation is an important direction for managing heavy metal pollution. Zn pollution has gradually become apparent, but there are few reports about its pollution remediation. Here, the Zn remediation potential of , an anamorph of the entomopathogenic fungus , was explored.

Ultrafast synthesis of halogen-doped Ru-based electrocatalysts with electronic regulation for hydrogen generation in acidic and alkaline media.

Developing a facile and time-saving method for preparing hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) electrocatalysts can accelerate the practical applications of hydrogen energy. In this study, halogen (X = F, Cl, Br and I) doped Ru-RuO on carbon cloth (CC) (X-Ru-RuO/MCC) was synthesized via an ultrafast microwave-assisted method for 30 s. Particularly, the doped Br (Br-Ru-RuO/MCC) significantly improved the electrocatalytic performances of the catalyst through the regulation of electronic structures.

A semiconductive copper iodobismuthate hybrid: structure, optical properties and photocurrent response.

Pursuits of new types of Pb-free heterometallic halides adequate for photovoltaic applications are still urgent but challenging. In this study, by using -produced [(Me)-(DABCO)] (DABCO = 1,4-diazabicyclo[2.2.

Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathway.

Presently, the supply of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) traditionally produced by marine fisheries will be insufficient to meet their market demand in food industry. Thus a sustainable alternative source is urgently required. Schizochytrium sp.

The critical role of ferritinophagy in human disease.

Ferritinophagy is a type of autophagy mediated by nuclear receptor activator 4 (NCOA4), which plays a role in inducing ferroptosis by regulating iron homeostasis and producing reactive oxygen species in cells. Under physiological conditions, ferritinophagy maintains the stability of intracellular iron by regulating the release of free iron. Studies have demonstrated that ferritinophagy is necessary to induce ferroptosis; however, under pathological conditions, excessive ferritinophagy results in the release of free iron in large quantities, which leads to lipid peroxidation and iron-dependent cell death, known as ferroptosis.

Two [Co(bipy)]-Templated Silver Halobismuthate Hybrids: Syntheses, Structures, Photocurrent Responses, and Theoretical Studies.

Employing in situ-generated metal complexes as structural decorating agents, we, for the first time, isolated two [Co(bipy)]-templated silver halobismuthate hybrids, namely [Co(bipy)]AgBiX (X = Br (), I (); bipy = 2,2'-bipyridine). Compounds and belong to the isomorphic phrases and exhibit the nonperovskite structures characteristic of the discrete [AgBiX] anions. UV-vis absorption spectra analyses showed that the optical band gaps of compounds and are 2.

Anisodamine potently inhibits SARS-CoV-2 infection in vitro and targets its main protease.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provoked a pandemic of acute respiratory disease, namely coronavirus disease 2019 (COVID-19). Currently, effective drugs for this disease are urgently warranted. Anisodamine is a traditional Chinese medicine that is predicted as a potential therapeutic drug for the treatment of COVID-19.

Reliability of a Novel Automatic Knee Arthrometer for Measuring Knee Laxity After Anterior Cruciate Ligament Ruptures.

Background: The accuracy of existing devices for measuring knee laxity is adversely affected by examiner reliability.

Purpose: To compare the accuracy of a novel automatic knee arthrometer (AKA) to that of the KT-2000 arthrometer for measuring knee laxity after anterior cruciate ligament (ACL) ruptures.

Study Design: Cohort study; Level of evidence, 2.

Enhancement of polysaccharides production using microparticle enhanced technology by Paraisaria dubia.

Background: Polysaccharides are important active ingredients in Ophiocordyceps gracilis with many physiological functions. It can be obtained from the submerged fermentation by the anamorph (Paraisaria dubia) of Ophiocordyceps gracilis. However, it was found that the mycelial pellets of Paraisaria dubia were dense and increased in volume in the process of fermentation, and the center of the pellets was autolysis due to the lack of nutrient delivery, which extremely reduced the yield of polysaccharides.

Polygenic Score for Smoking is associated with Externalizing Psychopathology and Disinhibited Personality Traits but not Internalizing Psychopathology in Adolescence.

We examined whether a polygenic score (PGS) for smoking measured genetic risk for general behavioral disinhibition by estimating its associations with externalizing and internalizing psychopathology and related personality traits at multiple time points in adolescence (ages 11, 14, and 17 years; = 3225). The smoking PGS had strong associations with the stable variance across time for all the externalizing measures (mean standardized = .27), agreeableness ( = -.

Four Discrete Silver Iodobismuthates/Bromobismuthates with Metal Complexes: Syntheses, Structures, Photocurrent Responses, and Theoretical Studies.

Using formed metal complexes of [Fe(bipy)] or [Ni(bipy)] (bipy = 2,2'-bipyridine) as templates, four new Ag-Bi-X (X = I and Br) compounds are first isolated in the metal-complex-decorated heterometallic halobismuthate family, namely [M(bipy)]AgBiI (M = Fe (), Ni ()), [Fe(bipy)]AgBiBr (), and [Ni(bipy)]AgBiBr (). Compounds - feature discrete [AgBiX] anions, exhibiting three polymorphisms that may be ascribed to the different stackings and the flexible condensations of [BiX] octahedrons and [AgX] tetrahedra/[AgX] triangles. UV-vis diffuse reflectance analyses reveal that they are narrow band gap semiconductor materials (ca.