Sesamin alleviates lipid accumulation induced by oleic acid via PINK1/Parkin-mediated mitophagy in HepG2 cells.

Sesamin, a special compound present in sesame and sesame oil, has been reported a role in regulating lipid metabolism, while the underlying mechanisms remain unclear. Autophagy has been reported associated with lipid metabolism and regarded as a key modulator in liver steatosis. The present work aimed to investigate whether sesamin could exert its protective effects against lipid accumulation via modulating autophagy in HepG2 cells stimulated with oleic acid (OA).

Influence of Proppant Size on the Proppant Embedment Depth.

Hydraulic fracturing is a well stimulation technique involving the fracturing of bedrock formations by a pressurized liquid, in which proppants are added to keep the fracture open after the fracturing operation. The scale discrepancy between the rock specimen and the proppant may bring deviations in the analysis of proppant embedment depth if the fluid-deteriorated formation is treated as an isotropic medium. This study tries to uncover the origins of these deviations through numerical and analytical analyses.