Flexible Fiber Sensors for Real-Time Monitoring of Redox Signaling Molecules in Exercise-Mimicking Engineered Skeletal Muscle.

Real-time monitoring of reactive oxygen and nitrogen species (RONS) in skeletal muscle provides crucial insights into the cause-and-effect relationships between physical activity and health benefits. However, the dynamic production of exercise-induced RONS remains poorly explored, due to the lack of sensing tools that can conform to soft skeletal muscle while monitor RONS release during exercise. Here we introduce dual flexible sensors via twisting carbon nanotubes into helical bundles of fibers and subsequent assembling electrochemical sensing components.

Mediating role of anxiety between body image distress and quality of life among women with polycystic ovary syndrome: a multicentre cross-sectional study.

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Body image distress (BID) refers to psychological distress caused by deviations in the individual's self-aesthetic ability. The objectives of this study are to investigate the prevalence of psychological distress; and to assess the role of anxiety in the relationship between body image distress and quality of life (QoL) among women with polycystic ovary syndrome using a path analysis approach.

5G-based collaborative trajectory following modeling and enhancement in connected and automated airspace environment.

In an emerging trajectory-based operation (TBO) environment within the advanced autonomous airspace, traffic operation along reference trajectories can function as trajectory-following mechanisms. However, 5G-based following dynamics still remain underexplored, limiting further utilization of lower-latency 5G technology other than data links. This limitation affects air traffic stability when encountering disturbance, preventing autonomous airspeed adjustment, and safe separation without air traffic controller interventions.

Association of Hyperautofluorescence Signals with Geographic Atrophy Progression in the METformin for the MINimization of Geographic Atrophy Progression Trial.

Purpose: To investigate the association between rim area focal hyperautofluorescence (RAFH) signals and geographic atrophy (GA) growth rates, as well as the impact of oral metformin on the longitudinal change of RAFH.

Design: Secondary analysis of a randomized controlled trial.

Participants: Seventy-one eyes from 44 participants with GA and ≥6 months of follow-up in the METformin for the MINimization of geographic atrophy progression study.

Analysis of Trace Enrofloxacin in Environmental Waters by a Surface Molecular Imprinting Technique.

Surface-imprinted polymers (ZIF-67@MIPs) supported by ZIF-67 were prepared by precipitation polymerization using enrofloxacin (ENR) as the template molecule, methacrylic acid as the functional monomer, and ethylene glycol dimethacrylate as the cross-linker. ZIF-67@MIPs were characterized by Fourier transform infrared spectrometry, X-ray diffraction, scanning electron microscopy, and particle size distribution. The adsorption performance of the polymer was studied.

A Fast Transient Response Capacitor-Less LDO with Transient Enhancement Technology.

This paper proposes a fast transient load response capacitor-less low-dropout regulator (CL-LDO) for digital analog hybrid circuits in the 180 nm process, capable of converting input voltages from 1.2 V to 1.8 V into an output voltage of 1 V.

Automated localization of mandibular landmarks in the construction of mandibular median sagittal plane.

Objective: To use deep learning to segment the mandible and identify three-dimensional (3D) anatomical landmarks from cone-beam computed tomography (CBCT) images, the planes constructed from the mandibular midline landmarks were compared and analyzed to find the best mandibular midsagittal plane (MMSP).

Methods: A total of 400 participants were randomly divided into a training group (n = 360) and a validation group (n = 40). Normal individuals were used as the test group (n = 50).

METformin for the MINimization of Geographic Atrophy Progression (METforMIN): A Randomized Trial.

Purpose: Metformin use has been associated with a decreased risk of age-related macular degeneration (AMD) progression in observational studies. We aimed to evaluate the efficacy of oral metformin for slowing geographic atrophy (GA) progression.

Design: Parallel-group, multicenter, randomized phase II clinical trial.

Progress of stimulus responsive nanosystems for targeting treatment of bacterial infectious diseases.

In recent decades, due to insufficient concentration at the lesion site, low bioavailability and increasingly serious resistance, antibiotics have become less and less dominant in the treatment of bacterial infectious diseases. It promotes the development of efficient drug delivery systems, and is expected to achieve high absorption, targeted drug release and satisfactory therapy effects. A variety of endogenous stimulation-responsive nanosystems have been constructed by using special infection microenvironments (pH, enzymes, temperature, etc.

Integration of mRNA and miRNA analysis reveals the molecular mechanisms of sugar beet (Beta vulgaris L.) response to salt stress.

The continuous increase of saline-alkali areas worldwide has led to the emergence of saline-alkali conditions, which are the primary abiotic stress or hindering the growth of plants. Beet is among the main sources of sugar, and its yield and sugar content are notably affected by saline-alkali stress. Despite sugar beet being known as a salt-tolerant crop, there are few studies on the mechanisms underlying its salt tolerance, and previous studies have mainly delineated the crop's response to stress induced by NaCl.

A Fast Transient Adaptive On-Time Controlled BUCK Converter with Dual Modulation.

This paper proposed a fully integrated adaptive on-time (AOT) controlled buck converter with fast load transient. An adaptive on-time generator is presented to stabilize the output frequency. To enhance the light load efficiency, the converter could transfer from the pulse width modulation (PWM) to pulse skip modulation (PSM) as the load current decreases.

Identification and Expression Analysis of Gene Family in L.

Dihydroflavonol 4-reductase () is a key enzyme in the flavonoid biosynthetic pathway and is essential for the formation of plants' color. In this study, 26 genes were identified using 6 genes as reference. The physicochemical properties, subcellular localization, and conserved structure of proteins were analyzed; the evolutionary relationship, collinearity analysis, and expression characteristics of genes were studied; and the correlation between the expression level of genes and anthocyanin content in rape petals were analyzed.

Improving Performance of AlO/AlN/GaN MIS HEMTs via In Situ N Plasma Annealing.

A novel monocrystalline AlN interfacial layer formation method is proposed to improve the device performance of the fully recessed-gate AlO/AlN/GaN Metal-Insulator-Semiconductor High Electron Mobility Transistors (MIS-HEMTs), which is achieved by plasma-enhanced atomic layer deposition (PEALD) and in situ N plasma annealing (NPA). Compared with the traditional RTA method, the NPA process not only avoids the device damage caused by high temperatures but also obtains a high-quality AlN monocrystalline film that avoids natural oxidation by in situ growth. As a contrast with the conventional PELAD amorphous AlN, results indicated a significantly lower interface density of states () in a MIS characterization, which could be attributed to the polarization effect induced by the AlN crystal from the X-ray Diffraction (XRD) and Transmission Electron Microscope (TEM) characterizations.

Blending controlled-release urea and urea under ridge-furrow with plastic film mulching improves yield while mitigating carbon footprint in rainfed potato.

Ridge-furrow with plastic film mulching and various urea types have been applied in rainfed agriculture, but their interactive effects on potato (Solanum tuberosum L.) yield and especially environments remain poorly understood. A three-year experiment was conducted to explore the responses of tuber yield, methane (CH) and nitrous oxide (NO) emissions, net global warming potential (NGWP), carbon footprint (CF), and net ecosystem economic budget (NEEB) of rainfed potato to two mulching practices [plastic film mulching (RM) and no plastic film mulching (NM)] and three urea types [conventional urea (U), controlled-release urea (C), and a mixture of equal amounts of conventional urea and controlled-release urea at a ratio of 1:1 (CU)] and their interactions.

ABC Transporters and CYP3A4 Mediate Drug Interactions between Enrofloxacin and Salinomycin Leading to Increased Risk of Drug Residues and Resistance.

Enrofloxacin (ENR) is one of the most common drugs used in poultry production to treat bacterial diseases, and there is a high risk of drug interactions (DDIs) between polyether anticoccidial drugs added to poultry feed over time. This may affect the efficacy of antibiotics or lead to toxicity, posing a potential risk to the environment and food safety. This study aimed to investigate the DDI of ENR and salinomycin (SAL) in broilers and the mechanism of their DDI.

The influence of the topographic location of geographic atrophy on vision-related quality of life in nonexudative age-related macular degeneration.

Purpose: To examine associations between the topographic distribution of geographic atrophy (GA) and vision-related quality of life (VRQoL).

Methods: This study included 237 eyes from 161 participants in the Age-Related Eye Disease Study (AREDS). GA lesions were manually delineated with color fundus photographs obtained by the AREDS Research Group and atrophic area was measured in an Early Treatment Diabetic Retinopathy Study (ETDRS) grid.

Relationship between gut microbiota and lymphocyte subsets in Chinese Han patients with spinal cord injury.

This study is to investigate the changes of lymphocyte subsets and the gut microbiota in Chinese Han patients with spinal cord injury (SCI). We enrolled 23 patients with SCI and 21 healthy controls. Blood and fecal samples were collected.

Local Progression Kinetics of Geographic Atrophy Depends Upon the Border Location.

Purpose: To assess the influence of lesion morphology and location on geographic atrophy (GA) growth rate.

Methods: We manually delineated GA on color fundus photographs of 237 eyes in the Age-Related Eye Disease Study. We calculated local border expansion rate (BER) as the linear distance that a point on the GA border traveled over 1 year based on a Euclidean distance map.

The roles of cadmium on growth of seedlings by analysing the composition of metabolites in pumpkin tissues.

Changes in the types and contents of metabolites in plants can occur in response to environmental stress. In this study, pumpkin seeds were cultivated in a cadmium ion solution (cadmium sulfate) for 7 days, and growth parameters, antioxidant enzyme activities, and metabolites in the root, stem, and leaf were analyzed. The results showed that cadmium accumulation characteristics were in the order of root > stem > leaf.

Associations of systemic health and medication use with the enlargement rate of geographic atrophy in age-related macular degeneration.

Background: The associations of geographic atrophy (GA) progression with systemic health status and medication use are unclear.

Methods: We manually delineated GA in 318 eyes in the Age-Related Eye Disease Study. We calculated GA perimeter-adjusted growth rate as the ratio between GA area growth rate and mean GA perimeter between the first and last visit for each eye (mean follow-up=5.

Geographic atrophy severity and mortality in age-related macular degeneration.

Purpose: To examine the association between geographic atrophy (GA) disease characteristics and mortality risk.

Methods: We manually delineated color fundus photographs of 209 Age-Related Eye Disease Study (AREDS) participants with GA secondary to age-related macular degeneration to identify total area of atrophy, GA effective radius growth rate, disease laterality, and the presence of foveal center involvement. Associations between GA characteristics and mortality were assessed with Cox proportional hazards models adjusted for health status indicators.

Natural history of central sparing in geographic atrophy secondary to non-exudative age-related macular degeneration.

Background: The macular central 1 mm diameter zone is crucial to patients' visual acuity, but the long-term natural history of central sparing in eyes with geographic atrophy (GA) is unknown.

Methods: We manually segmented GA in 210 eyes with GA involving central 1 mm diameter zone (mean follow-up=3.8 years) in the Age-Related Eye Disease Study.

Geographic Atrophy Growth Is Strongly Related to Lesion Perimeter: Unifying Effects of Lesion Area, Number, and Circularity on Growth.

Purpose: To investigate the underlying reason for the previously observed impact of baseline lesion size, number, and circularity on geographic atrophy (GA) growth rate.

Design: Retrospective analysis of a multicenter, prospective, randomized controlled trial.

Participants: Age-Related Eye Disease Study participants with GA secondary to nonexudative age-related macular degeneration.