Publications by authors named "Mengyuan Ni"
Objective: The Triglyceride-glucose Index (TyG) index is a dependable metric for assessing the degree of insulin resistance, serving as a standalone predictor of ischemic stroke risk, but its precise relationship with early neurological deterioration (END) remains incompletely expounded within the context of acute mild ischemic stroke patients. This research is to examine the correlation of the TyG index with END among patients experiencing acute mild ischemic stroke in China.
Methods: This retrospective analysis was conducted to systematically gather data regarding patients experiencing their maiden episode of acute mild ischemic stroke and hospitalized at the Neurology Department of Nanjing Meishan Hospital, located in Nanjing, Jiangsu Province, China, over the period extending from January 2020 to December 2022.
Erratum to: Biallelic variants in HPDL cause pure and complicated hereditary spastic paraplegia.
Brain
September 2021
Article Synopsis
- Human 4-hydroxyphenylpyruvate dioxygenase-like (HPDL) is an iron-containing non-heme oxygenase linked to various neurological disorders in 34 individuals from 25 families with biallelic HPDL variants.
- These neurological disorders presented as conditions ranging from juvenile-onset spastic paraplegia to infantile-onset spasticity, often accompanied by severe developmental delays and respiratory issues.
- Experiments showed that HPDL is expressed in the nervous system, plays a role in motor function in zebrafish models, and its variants disrupt enzymatic function, suggesting a causative link between HPDL mutations and neurological diseases.
A mild reaction for DNA-compatible, palladium promoted Suzuki-Miyaura cross-coupling reaction of potassium Boc-protected aminomethyltrifluoroborate with DNA-conjugated aryl bromides has been developed efficiently. This novel DNA encoded chemistry reaction proceeded well with a wide range of functional group tolerance, including aryl bromides and heteroaryl bromides. Further, the utility our DNA conjugated aminomethylated arene products is demonstrated by reaction with various types of reagents (including amide formation with carboxylic acids, alkylation with aldehydes, and carbamoylation with amines) as would be desired for the production of a DNA encoded library.
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- 4-Hydroxyphenylpyruvate dioxygenase (HPPD) is crucial for breaking down tyrosine, and a lack of it leads to type III tyrosinaemia.
- The study focused on the N-terminus of HPPD, which affects enzyme activity, showing that its removal significantly decreases catalytic efficiency.
- Molecular dynamics simulations indicated that flexibility at the N-terminus disrupts the stability needed for effective catalysis, highlighting its importance for HPPD function.