Diterpenoids and Triterpenoids from the Aerial Parts of and Their Biological Activities.

Five undescribed diterpenoids, serranins A-E (-), and four novel triterpenoids, serratic acids A-D (-), along with 32 known terpenoids (-) were isolated from the aerial parts of . The planar structures of - and their relative configurations were established on the basis of extensive spectroscopic analysis. Structurally, compounds - are the first examples of 18,19--ursane -coumaric or ferulic esters, while compounds - further enriched the plant's diterpene profile.

Polystyrene microplastics induce molecular toxicity in Simocephalus vetulus: A transcriptome and intestinal microorganism analysis.

The global prevalence and accumulation of plastic waste is leading to pollution levels that cause significant damage to ecosystems and ecological security. Exposure to two concentrations (1 and 5 mg/L) of 500 nm polystyrene (PS)-nanoplastics (NPs) for 14 d was evaluated in Simocephalus vetulus using transcriptome and 16 s rRNA sequencing analyses. PS-NP exposure resulted in stress-induced antioxidant defense, disturbed energy metabolism, and affected the FoxO signaling pathway, causing neurotoxicity.

NMR-Guided Isolation of Anti-inflammatory Carabranolides from the Fruits of L.

Carabranolides present characteristic NMR resonances for the cyclopropane moiety, which distinctly differ from those of other compounds and were used for an NMR-guided isolation in this study. As a result, 11 undescribed carabranolides (-), along with five known ones (-), were isolated from the fruits of L. Compounds - are new esters of carabrol at C-4 with different carboxylic acids.

Boswellianols A-I, Structurally Diverse Diterpenoids from the Oleo-Gum Resin of and Their TGF- Inhibition Activity.

Olibanum, a golden oleo-gum resin from species in the genus ( family), is a famous traditional herbal medicine widely used around the world. Previous phytochemical studies mainly focused on the non-polar fractions of olibanum. In this study, nine novel diterpenoids, boswellianols A-I (-), and three known compounds were isolated from the polar methanolic fraction of the oleo-gum resin of .

Modulate the laser phase to improve the ns-LIBS spectrum signal based on orbital angular momentum.

Aiming to enhance the ns-LIBS signal, in this work, we introduced orbital angular momentum to modulate the laser phase of the Gaussian beam into the vortex beam. Under similar incident laser energy, the vortex beam promoted more uniform ablation and more ablation mass compared to the Gaussian beam, leading to elevated temperature and electron density in the laser-induced plasma. Consequently, the intensity of the ns-LIBS signal was improved.

Neuroprotective mechanism of ribisin A on HO-induced PC12 cell injury model.

Ribisin A has been shown to have neurotrophic activity. The aim of this study was to evaluate the neuroprotective effect of ribisin A on injured PC12 cells and elucidate its mechanism. In this project, PC12 cells were induced by H2O2 to establish an injury model.

Cevanine-type alkaloids from the bulbs of Fritillaria unibracteata var. wabuensis and their antifibrotic activities in vitro.

Steroidal alkaloids are the main bioactive components of the bulbs of Fritillaria, which have been used as traditional Chinese medicine, known as "Beimu", for the treatment of cough for thousands of years in China. Cough and dyspnea are the most common symptoms observed in patients with pulmonary fibrosis. However, the antifibrotic activity of steroidal alkaloids has not been reported yet.

[Neuropsychological development of large for gestational age infants at the age of 12 months].

Objectives: To investigate the level of neuropsychological development in large for gestational age (LGA) infants at the age of 12 months.

Methods: The infants, aged 12 to <13 months, who attended the Outpatient Service of Child Care in the First Affiliated Hospital of Shandong First Medical University from December 2021 to June 2023, were enrolled as subjects. According to the gestational age and birth weight, they were divided into preterm appropriate for gestational age (AGA) group, preterm LGA group, early term AGA group, early term LGA group, full-term AGA group, and full-term LGA group.

Full-Stokes polarization laser-induced breakdown spectroscopy detection of infiltrative glioma boundary tissue.

The glioma boundary is difficult to identify during surgery due to the infiltrative characteristics of tumor cells. In order to ensure a full resection rate and increase the postoperative survival of patients, it is often necessary to make an expansion range resection, which may have harmful effects on the quality of the patient's survival. A full-Stokes laser-induced breakdown spectroscopy (FSLIBS) theory with a corresponding system is proposed to combine the elemental composition information and polarization information for glioma boundary detection.

Sesquiterpenoids from the roots of Aucklandia costus and their anti-inflammatory activities.

Five undescribed sesquiterpenoid dimers, aucklandiolides A-E (1-5), one new sesquiterpenoid glycoside, β-cyclocostunolide-15-β-D-glucopyranoside (6), and seventeen known analogues (7-23) were isolated from the roots of Aucklandia costus. Their structures were elucidated by comprehensive HRESIMS and NMR spectroscopic data analysis, and their configurations were confirmed by the computational calculations of ECD and NMR chemical shifts. Aucklandiolides A and B are the first examples of dimeric sesquiterpenoids with a unique 6/6/6/5/6/6 ring system originated from a proposed Diels-Alder cycloaddition between two eudesmane sesquiterpenoids.

Rapid Test for Adulteration of Fritillaria Thunbergii in Fritillaria Cirrhosa by Laser-Induced Breakdown Spectroscopy.

Fritillaria has a long history in China, and it can be consumed as medicine and food. Owing to the high cost of Fritillaria cirrhosa, traders sometimes mix it with the cheaper Fritillaria thunbergii powder to make profit. Herein, we proposed a laser-induced breakdown spectroscopy (LIBS) technique to test the adulteration present in the sample of Fritillaria cirrhosa powder.

Phelliribsin B: A New Styrylpyrone Derivative from the Medicinal Fungus Phellinus ribis.

A novel styrylpyrone derivative, named phelliribsin B (1), as well as four biogenetically related known compounds, phellifuropyranone A (2), inoscavin C (3), inoscavin A (4), and inoscavin D (5) were separated and purified from the medicinal fungus Phellinus ribis. The structure of phelliribsin B was determined by spectroscopic analysis, and the absolute configuration was assigned by experimental and calculated ECD data. Additionally, the plausible biosynthetic pathway of 1 was also proposed.